Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells.
Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells.
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DOI：
10.1007/978-3-319-55947-6_11
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发表时间：
2017
影响因子：
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通讯作者：
S. Werner;A. Stenzl;K. Pantel;T. Todenhöfer
中科院分区：
文献类型：
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作者：
S. Werner;A. Stenzl;K. Pantel;T. Todenhöfer
循环肿瘤细胞（CTC）的表征 不仅有可能为晚期肿瘤疾病的分子改变提供重要的见解，而且还有助于风险预测。上皮间质转化（EMT）已被发现是肿瘤细胞转移和扩散到血流中的重要过程。在不同的肿瘤类型中，已经报道了具有间充质表型的CTC可能经历了EMT。此外，CTC 具有干细胞样特征的肿瘤细胞已经被假定为肿瘤进展的重要驱动因素。已经引入了不同的平台以允许CTC富集而不依赖于上皮抗原的表达，因为这些抗原可以在EMT或干细胞样CTC中下调。对于具有EMT或干细胞特征的CTC， 已经提出了不同的标记。然而，仍然缺乏证据表明这些标记物与干细胞和经历EMT的细胞的功能特征和特性相关。
The characterization of circulating tumor cells (CTC) has the potential not only to provide important insights into molecular alterations of advanced tumor disease but also to facilitate risk prediction. Epithelial mesenchymal transition (EMT) has been discovered as important process for the development of metastases and the dissemination of tumor cells into the blood stream. In different tumor types, CTC with a mesenchymal phenotype have been reported that have presumably underwent EMT. Moreover, CTC with stem-cell like characteristics have been postulated as important drivers of tumor progression. Different platforms have been introduced to allow CTC enrichment independent of expression of epithelial antigens, as these may be downregulated in EMT- or stem-cell-like CTC. Both for CTCs with EMT- or stem-cell features different markers have been proposed. However, there is still a lack of evidence on the association of these markers with functional features and characteristics for stem cells and cells undergoing EMT.