Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet
Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet
复制标题
低钠或高钠饮食中与血压相关的尿液代谢物
DOI：
10.7150/thno.22018
复制
发表时间：
2018-01-01
期刊：
影响因子：
12.4
通讯作者：
Liang, Mingyu
中科院分区：
文献类型：
--
作者：
Cheng, Yuan;Song, Haiying;Liang, Mingyu
膳食盐的摄入对动脉血压和高血压的发生有显著影响。血压盐依赖性变化的机制仍然知之甚少，并且很难在临床上评估血压盐敏感性。方法：我们检测了103名饮食方法来停止高血压(DASH)-钠试验的参与者在近30天后的尿液代谢物水平，这些参与者的饮食包括高钠（目标是每天150 mmol的钠摄入量）或低钠（每天50 mmol）。对24 h尿样进行了47种氨基代谢物和10种与三羧酸循环相关的代谢物的靶向色谱/质谱分析。在达尔盐敏感大鼠中检测了一种鉴定的代谢物对血压的影响。结果：尿代谢物水平改善了基于种族、年龄和性别的血压盐敏感性分类的预测。随机森林和广义线性混合模型分析发现了显著的错误发现率
Dietary salt intake has significant effects on arterial blood pressure and the development of hypertension. Mechanisms underlying salt-dependent changes in blood pressure remain poorly understood, and it is difficult to assess blood pressure salt-sensitivity clinically.Methods: We examined urinary levels of metabolites in 103 participants of the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial after nearly 30 days on a defined diet containing high sodium (targeting 150 mmol sodium intake per day) or low sodium (50 mmol per day). Targeted chromatography/mass spectrometry analysis was performed in 24 h urine samples for 47 amino metabolites and 10 metabolites related to the tricarboxylic acid cycle. The effect of an identified metabolite on blood pressure was examined in Dahl salt-sensitive rats.Results: Urinary metabolite levels improved the prediction of classification of blood pressure salt-sensitivity based on race, age and sex. Random forest and generalized linear mixed model analyses identified significant (false discovery rate