Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions
Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions
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DOI：
10.1016/j.mri.2007.02.015
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发表时间：
2007-07-01
影响因子：
2.5
通讯作者：
Gruetter, Rolf
中科院分区：
文献类型：
--
作者：
van Heeswijk, Ruud B.;Laus, Sabrina;Gruetter, Rolf
研究了市售钆（Gd）基造影剂的弛豫率，用于X-核共振，其固有弛豫时间从6秒到几百秒不等。纯C-13甲酸中的Omniscan的弛豫率为2.9 mM（-1）s（-1），而其对水溶液中谷氨酸C1和C5的弛豫率与0.5 mM（-1）s（-1）相似。这两种弛豫率都允许制备具有预定短T的溶液，并表明在体外其测量中的显著灵敏度增益可以实现。Li-6具有长的固有弛豫时间，在几分钟的量级上，其强烈地受到造影剂的影响。弛豫率范围从Omniscan的0.1 mM（-1）s（-1）到Magnevist的0.3，而Gd-DOTP的弛豫率为11 mM（-1）s（-1），高出两个数量级。总之，这些实验表明，0.1- 10 μ M造影剂的存在应该是可检测的，提供足够的灵敏度是可用的，如超极化，最近引入体内成像提供。(c)2007年爱思唯尔公司All rights reserved.
The relaxivity of commercially available gadolinium (Gd)-based contrast agents was studied for X-nuclei resonances with long intrinsic relaxation times ranging from 6 s to several hundred seconds. Omniscan in pure C-13 formic acid had a relaxivity of 2.9 mM(-1) s(-1), whereas its relaxivity on glutamate C1 and C5 in aqueous solution was similar to 0.5 mM(-1) s(-1). Both relaxivities allow the preparation of solutions with a predetermined short T, and suggest that in vitro substantial sensitivity gains in their measurement call be achieved.Li-6 has a long intrinsic relaxation time, on the order of several minutes, which was strongly affected by the contrast agents. Relaxivity ranged from similar to 0.1 mM(-1) s(-1) for Omniscan to 0.3 for Magnevist, whereas the relaxivity of Gd-DOTP was at 11 mM(-1) s(-1), which is two orders of magnitude higher. Overall, these experiments suggest that the presence of 0.1- to 10-mu M contrast agents should be detectable, provided sufficient sensitivity is available, such as that afforded by hyperpolarization, recently introduced to in vivo imaging. (c) 2007 Elsevier Inc. All rights reserved.