Preliminary confirmation of the proposed link between reward-dependence traits and norepinephrine
Preliminary confirmation of the proposed link between reward-dependence traits and norepinephrine
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DOI：
10.1016/0165-1781(96)02954-x
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发表时间：
1996-11-01
影响因子：
11.3
通讯作者：
Blum, N
中科院分区：
文献类型：
--
作者：
Garvey, MJ;Noyes, R;Blum, N
人格的三维理论认为，属于被称为“奖励依赖”的人格谱的特征部分是由神经递质去甲肾上腺素（NE）决定的。我们假设尿中NE代谢物3-甲氧基-4-羟基苯基乙二醇（MHPG）的水平与三维人格问卷（TPQ）的奖励依赖得分显著相关。27名无精神疾病的受试者收集尿液进行MHPG测量并完成TPQ。奖励依赖得分与MHPG水平有显著相关。MHPG水平与其他两个人格维度（寻求新奇和避免伤害）无关。这项初步研究支持了奖励依赖性状部分由NE决定的假设。
The tridimensional theory of personality posits that traits belonging to a personality spectrum called 'reward dependence' are determined in part by the neurotransmitter norepinephrine (NE). We hypothesized that urinary levels of the NE metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) would be significantly correlated to the reward dependence score on the Tridimensional Personality Questionnaire (TPQ). Twenty-seven never psychiatrically ill subjects collected urine for MHPG measurements and completed the TPQ. There was a significant correlation between the reward dependence score and the level of MHPG. MHPG level was not associated with the other two personality dimensions, novelty seeking and harm avoidance. This preliminary study supports the hypothesis that reward-dependence traits are in part determined by NE.