RBF method for optimal control of drug administration in the anemia of hemodialysis patients
RBF method for optimal control of drug administration in the anemia of hemodialysis patients
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RBF 方法优化血液透析患者贫血给药控制
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
T. Inanc
中科院分区：
文献类型：
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作者：
Hossein Mirinejad;T. Inanc
贫血是终末期肾病（ESRD）的常见并发症，可通过重组人促红细胞生成素（EPO）有效治疗。虽然低剂量促红细胞生成素不能有效治疗贫血，但过量的促红细胞生成素可能会增加严重心脏问题和血栓的风险。因此，EPO给药的最优控制在贫血的治疗中具有重要意义。本文将径向基函数（RBF）方法成功地应用于促红细胞生成素的给药问题。仿真结果表明，该方法对血液透析患者贫血时EPO给药的最优控制是有效的。
Anemia is a common complication of the end-stage renal disease (ESRD) that is efficiently treated by the administration of recombinant human erythropoietin (EPO). While a low-dose EPO cannot treat the anemia effectively, an excessive EPO dose may increase the risk of serious heart problems and blood clots. Therefore, the optimal control of EPO administration is of great importance in the treatment of anemia. In this work, a radial basis function (RBF) method is introduced and successfully applied to the EPO drug dosing problem. The simulation results show the effectiveness of the method for the optimal control of EPO administration in the anemia of hemodialysis patients.