High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease
High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease
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DOI：
10.1016/j.jns.2006.02.009
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发表时间：
2006-07-15
影响因子：
4.4
通讯作者：
Mishima, Hiromu K.
中科院分区：
文献类型：
--
作者：
Tamura, Hiroki;Kawakami, Hideshi;Mishima, Hiromu K.
阿尔茨海默病（AD）与青光眼之间的临床和遗传关系尚不清楚。本研究的目的是确定日本AD患者开角型青光眼（OAG）的患病率，以及载脂蛋白E (APOE) 4等位基因是否与AD相关，无论是否伴有OAG。这些组包括172名符合AD诊断标准的患者和176名年龄匹配的对照组。进行眼科检查，并通过PCR和酶切产物进行基因组分析。AD患者中OAG发生率为41例（23.8%），显著高于对照组（9.9%）（p=0.0002）。此外，有OAG和无OAG的AD患者眼压（IOPs）无显著差异。携带APOE epsilon 4等位基因的AD患者比例（29.5%）显著（p=0.0007）高于对照组（9.1%）。然而，患有OAG的AD患者携带APOE ε 4等位基因的比例（35.7%）与没有OAG的AD患者（27.7%,p=0.42）没有显著差异。综上所述，OAG在日本AD患者中的患病率较高，提示APOE以外的共同因素可能导致这两种疾病。(c) 2006 Elsevier B.V.版权所有
The clinical and genetic relationships between Alzheimer's disease (AD) and glaucoma remain obscure. The aim of this study was to determine the prevalence of open-angle glaucoma (OAG) in patients with AD and whether the apolipoprotein E (APOE) 4 allele is associated with AD, with or without OAG, in Japanese. The groups consisted of 172 patients with the diagnostic criteria of AD and 176 age-matched controls. Ophthalmic examinations were conducted, and genomic analysis was performed by PCR and digestion of products with an enzyme. OAG was found in 41 (23.8%) of the AD patients, which was a significantly (p=0.0002) higher prevalence than that in the controls (9.9%). Furthermore, there was no significant difference between intraocular pressures (IOPs) in AD patients with OAG and without OAG. The percentage of AD patients who carried an APOE epsilon 4 allele (29.5%) was significantly (p=0.0007) higher than that of the controls (9.1%). However, the percentage of AD patients with OAG who carried an APOE epsilon 4 allele (35.7%) was not significantly different than that of AD patients without OAG (27.7%, p=0.42). In summary, the prevalence of OAG is high in Japanese patients with AD, suggesting that common factors other than APOE may contribute to the two diseases. (c) 2006 Elsevier B.V. All rights reserved.