Relationship between blood alcohol concentration and carbohydrate-deficient transferrin among drivers
Relationship between blood alcohol concentration and carbohydrate-deficient transferrin among drivers
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DOI：
10.1016/j.drugalcdep.2005.01.017
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发表时间：
2005-08-01
影响因子：
4.2
通讯作者：
Wennig, R
中科院分区：
文献类型：
--
作者：
Appenzeller, BMR;Schneider, S;Wennig, R
对从 1260 名被捕司机中随机抽取并进行血液酒精浓度 (BAC) 测定的 408 份血液样本中的碳水化合物缺乏转铁蛋白 (CDT) 进行了定量。该研究的第一步是观察基于 BAC 的预评估是否与决定对司机进行慢性酒精滥用测试是否相关。为了这个目的。慢性酒精滥用的诊断通过 CDT 定量进行验证，自愿高阳性截止值固定在 3%，以实现高特异性。结果显示，随着BAC的增加，慢性酗酒者的比例显着增加：少数酗酒者的BAC类别低于0.5 g/L，而当BAC在3至3.5 g/L和高于3.5 g/L时，其频率分别增加至47%和67%。 其次。通过观察 CDT 值异常升高的驾驶员是否具有较高的 BAC，研究了生物标志物 CDT 在交通安全方面的有用性。 CDT 低于 1% 的驾驶员的平均 BAC 为 1.32 g/L，CDT 高于 3% 的驾驶员则增加至 2.28 g/L。统计分析显示，BAC 和 CDT 之间存在单调增加的联系（P < 0.0001）。我们在此证实了在测试驾驶员中的慢性酒精滥用之前基于 BAC 的预评估的相关性，并证明 CDT 是适合交通安全背景的生物标志物，因为 CDT 增加的驾驶员的 BAC 显着较高。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Carbohydrate-deficient transferrin (CDT) was quantified in 408 blood specimens, randomly selected from 1260 drivers apprehended and submitted to blood alcohol concentration (BAC) determination.The first step of the study was to observe whether a BAC based pre-evaluation was relevant for deciding to test drivers for chronic alcohol abuse. For this purpose. the diagnosis of chronic alcohol abuse was verified by CDT quantification, with a voluntary high positive cut-off fixed at 3% for high specificity. The results display a significant increase in the part of chronic alcohol abusers with respect to increasing BAC: a few alcohol abusers were present in the BAC category below 0.5 g/L, and their frequency increased to 47 and 67% when BAC was between 3 and 3.5 g/L and above 3.5 g/L, respectively.Secondly. the usefulness of the biomarker CDT in the traffic safety context was investigated by observing whether drivers with abnormally increased CDT value had also higher BAC. The average BAC was 1.32 g/L in drivers with CDT below 1 %, and increased to 2.28 g/L in drivers with CDT above 3%. Statistical analysis showed evidence of a monotone increasing link between BAC and CDT (P < 0.0001).We confirmed here the relevance of BAC-based pre-evaluation before testing chronic alcohol abuse among drivers, and demonstrated that CDT is a biomarker suitable for traffic safety context, as drivers with increased CDT had significantly higher BAC. (c) 2005 Elsevier Ireland Ltd. All rights reserved.