Calibrated fMRI for mapping absolute CMRO2: Practicalities and prospects
Calibrated fMRI for mapping absolute CMRO2: Practicalities and prospects
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DOI：
10.1016/j.neuroimage.2018.03.068
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发表时间：
2019-02-15
期刊：
影响因子：
5.7
通讯作者：
Wise, R. G.
中科院分区：
文献类型：
--
作者：
Germuska, M.;Wise, R. G.
功能磁共振成像（fMRI）是现代神经科学的重要工具，为大脑的功能组织提供了有价值的见解。血氧水平依赖性（BOLD）效应的生理机制是复杂的，并排除了对信号的直接解释。然而，通过对BOLD信号进行适当的校准，可以定量测量重要的生理参数，包括脑代谢耗氧量或氧代谢的绝对速率（cro2）和氧提取（OEF）。绘制这些基本参数的能力有可能极大地扩展功能磁共振成像的效用，并扩大其在临床研究和临床实践中的应用范围。在这篇综述文章中，我们讨论了一些与校准功能磁共振成像方法测量cmor2相关的实际问题。我们概述了确保高质量数据采集的必要预防措施，并探讨了在广泛的疾病和研究问题中应用和解释数据时必须考虑的一些陷阱和挑战。
Functional magnetic resonance imaging (fMRI) is an essential workhorse of modern neuroscience, providing valuable insight into the functional organisation of the brain. The physiological mechanisms underlying the blood oxygenation level dependent (BOLD) effect are complex and preclude a straightforward interpretation of the signal. However, by employing appropriate calibration of the BOLD signal, quantitative measurements can be made of important physiological parameters including the absolute rate of cerebral metabolic oxygen consumption or oxygen metabolism (CMRO2) and oxygen extraction (OEF). The ability to map such fundamental parameters has the potential to greatly expand the utility of fMRI and to broaden its scope of application in clinical research and clinical practice. In this review article we discuss some of the practical issues related to the calibrated-fMRI approach to the measurement of CMRO2. We give an overview of the necessary precautions to ensure high quality data acquisition, and explore some of the pitfalls and challenges that must be considered as it is applied and interpreted in a widening array of diseases and research questions.