Co-localization of neuropeptide tyrosine and somatostatin immunoreactivity in neurons of individual subfields of the rat hippocampal region.
Co-localization of neuropeptide tyrosine and somatostatin immunoreactivity in neurons of individual subfields of the rat hippocampal region.
复制标题
神经肽酪氨酸和生长抑素免疫反应性在大鼠海马区各个亚区神经元中的共定位。
DOI：
10.1016/0304-3940(87)90551-9
复制
发表时间：
1987
影响因子：
2.5
通讯作者：
Chan-Palay,V
中科院分区：
文献类型：
--
作者：
Köhler,C;Eriksson,LG;Davies,S;Chan-Palay,V
用抗神经肽酪氨酸（NPY）和生长抑素（SOM）的抗体在同一组织切片上进行双标记实验，研究了这两种肽在大鼠海马细胞中的共定位。个别海马子字段显示大的变化，在相对数量的NPY和SOM免疫反应（-i）神经元。虽然内嗅区的SOM比NPY-1细胞丰富得多，但NPY-1细胞在阿蒙角的所有亚区（例如区域上级、区域下级）中占优势。两种肽在单个神经元中的共定位最高的是在区域下和齿状区，最低的是在海马后结构。在背侧海马中，含有NPY-1的SOM-1细胞的数量高于含有SOM-1的NPY-1细胞的数量。这种模式在海马后区被逆转。在腹侧水平，NPY-1和SOM-1共定位在单个细胞中的发生率在海马各亚区增加。
The co-localization of Neuropeptide tyrosine (NPY) and somatostatin (SOM) in rat hippocampal cells was studied in double labelling experiments using a combination of antibodies against the two peptides on the same tissue section. The individual hippocampal subfields show large variations in the relative number of NPY- and SOM-immunoreactive (-i) neurons. While the entorhinal area is far richer in SOM as compared to NPY-i cells, NPY-i cells predominate in all subfields (e.g. regio superior, regio inferior) of Ammon's horn. Co-localization of both peptides in single neurons was highest in regio inferior and in the area dentata and lowest in the retrohippocampal structures. In the dorsal hippocampus, the number of SOM-i cells containing NPY-i was higher than the number of NPY-i cells containing SOM-i. This pattern was reversed in the retrohippocampal region. At ventral levels the incidence of colocalization of NPY-and SOM-i in single cells increased in all hippocampal subfields.