Silicone derivatives for contact lenses: functionalization, chemical characterization, and cell compatibility assessment.
Silicone derivatives for contact lenses: functionalization, chemical characterization, and cell compatibility assessment.
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用于隐形眼镜的有机硅衍生物：功能化、化学表征和细胞兼容性评估。
DOI：
10.1163/156856295x00300
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Jozefowicz,M
中科院分区：
文献类型：
--
作者：
Migonney,V;Lacroix,MD;Ratner,BD;Jozefowicz,M
已经证明了具有各种化学基团的聚合物在沿着链的随机位点的环氧开环官能化。该反应在温和条件下在水溶液中进行，以尽量减少大分子链的降解。由具有环氧侧链的共聚物制成的有机硅镜片用 4-羟基丁酸钠盐进行功能化。通过 ESCA 和放射性示踪剂对羧化有机硅衍生物进行了表征。根据两种方法的数据得出的反应产率平均值为 30%；然而，如果优化环氧硅树脂镜片的制备条件，则后者可以提高高达50%或更多。将衍生的有机硅涂覆在培养板的孔中，以评估这些新聚合物与成纤维细胞系（McCoy's）的细胞相容性。没有观察到细胞毒性。
Epoxy ring-opening functionalization of polymers at random sites along chains with various chemical groups has been demonstrated. The reaction is performed in an aqueous solution under mild conditions in order to minimize degradation of the macromolecular chains. Silicone lenses made of copolymers with epoxy side chains were functionalized with 4-hydroxybutyric acid, sodium salt. The carboxylated silicone derivatives were characterized by ESCA and radiotracers. A mean value of 30% reaction yield was concluded, based upon data from both methods; nevertheless, the latter can be improved up to 50% or more if the conditions of preparation of the epoxydized silicone lenses are optimized. Derivatized silicones were coated in the wells of culture plates to evaluate the cell compatibility of these new polymers with a fibroblast cell line (McCoy's). No cellular toxicity was observed.