Fundamentals of Bowel Cancer for Biomedical Engineers.
Fundamentals of Bowel Cancer for Biomedical Engineers.
复制标题
DOI：
10.1007/s10439-023-03155-8
复制
发表时间：
2023-04
影响因子：
3.8
通讯作者：
Nelson, Bradley J.
中科院分区：
文献类型：
--
作者：
Tian, Jiyuan;Afebu, Kenneth Omokhagbo;Bickerdike, Andrew;Liu, Yang;Prasad, Shyam;Nelson, Bradley J.
关键词：
肠癌是一种由遗传易感性和环境因素共同作用引起的多因素疾病。对肠癌及其前驱病变的检测主要是通过在内窥镜检查时对结肠粘膜进行肉眼检查或通过横断面成像来完成的。大多数病例是在癌症已经处于晚期时诊断出来的。这些模式在早期阶段检测病变的可靠性较低，因为早期病变通常很小或很平。在尽可能早的阶段切除病变可以降低癌症死亡的风险，这在很大程度上是因为减少了后续转移的风险。在这篇综述中，我们总结了肠癌的起源及其转移机制。特别是，我们回顾了广泛的文献，涉及肠癌的生物力学及其测量技术，这些都与成功开发肠癌诊断设备有关。我们还回顾了现有的可用于临床的肠癌诊断技术。最后，我们概述了当前的临床需求，并强调了医疗机器人在早期肠癌诊断中的潜在作用。
Bowel cancer is a multifactorial disease arising from a combination of genetic predisposition and environmental factors. Detection of bowel cancer and its precursor lesions is predominantly performed by either visual inspection of the colonic mucosa during endoscopy or cross-sectional imaging. Most cases are diagnosed when the cancer is already at an advanced stage. These modalities are less reliable for detecting lesions at the earliest stages, when they are typically small or flat. Removal of lesions at the earliest possible stage reduces the risk of cancer death, which is largely due to a reduced risk of subsequent metastasis. In this review, we summarised the origin of bowel cancer and the mechanism of its metastasis. In particular, we reviewed a broad spectrum of literatures covering the biomechanics of bowel cancer and its measurement techniques that are pertinent to the successful development of a bowel cancer diagnostic device. We also reviewed existing bowel cancer diagnostic techniques that are available for clinical use. Finally, we outlined current clinical needs and highlighted the potential roles of medical robotics on early bowel cancer diagnosis.
登录
查看更多内容
影响因子：
--
作者：
Campos-da-Paz, Mariana;Dorea, Jose Garrofe;de Fatima Menezes Almeida Santos, Maria
通讯作者：
de Fatima Menezes Almeida Santos, Maria
影响因子：
--
作者：
Blachar, Arye;Graif, Moshe;Sosna, Jacob
通讯作者：
Sosna, Jacob
影响因子：
4.6
作者：
Dementyev, Artem;Jitosho, Rianna;Paradiso, Joseph A.
通讯作者：
Paradiso, Joseph A.
影响因子：
1.8
作者：
Arvelo F;Sojo F;Cotte C
通讯作者：
Cotte C
影响因子：
4.6
作者：
Bauer, Jessica;Emon, Md Abdul Bashar;Jung, Barbara
通讯作者：
Jung, Barbara