Injection in temporomandibular joint of rats. Description of technical protocol
Injection in temporomandibular joint of rats. Description of technical protocol
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DOI：
10.1515/pjvs-2017-0025
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发表时间：
2017-01-01
影响因子：
0.8
通讯作者：
Ottone, N. E.
中科院分区：
文献类型：
--
作者：
Fuentes, R.;Veuthey, C.;Ottone, N. E.
用于研究的动物模型的开发已经非常普及。骨关节炎是一种关节退行性病变，可导致软骨侵蚀、软骨细胞增殖和骨赘形成。本文旨在介绍一种在大鼠颞下颌关节内注射乙酸单钠诱发骨性关节炎的技术方法，为今后有关病理进展的研究分析和合理的治疗效果做出贡献。大鼠模型的使用可能是一个复杂的过程，因为它们的大小，但它们可以与人类的颞下颌关节进行比较，因为它们的特征相似，而且可以执行诊断和治疗方案来检测这种病理。
The development of animal models for research has been very diffused. Osteoarthritis is a joint degenerative pathology that induces cartilage erosion, chondrocyte proliferation and osteophyte formation. The aim of this paper is to present a technical procedure to perform the injection of monosodium iodine acetate in the temporomandibular joints of rats to generate osteoarthritis and to contribute to future research analysis related to pathology progression and proper treatment performance. The use of rat models may be a complex process because of their size, but they can be compared to the human temporomandibular joint due to the similar characteristics and the possibility of performing diagnosis and treatment protocols in order to detect this pathology.