Sensitivity of the cytologic diagnosis of cervical condyloma in comparison with HPV‐DNA hybridization studies
Sensitivity of the cytologic diagnosis of cervical condyloma in comparison with HPV‐DNA hybridization studies
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与 HPV-DNA 杂交研究相比，宫颈湿疣细胞学诊断的敏感性
DOI：
10.1002/dc.2840030315
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发表时间：
1987
影响因子：
1.3
通讯作者：
L. Gissmann
中科院分区：
文献类型：
--
作者：
A. Schneider;Gabriele Meinhardt;Ethel‐Michele De‐Villiers;L. Gissmann
宫颈尖锐湿疣的细胞学诊断是基于过去10年制定的标准。现在已经可以通过高度敏感的DNA过滤杂交技术直接在宫颈拭子中记录人乳头瘤病毒（HPV） DNA的存在。本文的目的是通过与相同材料的HPV - DNA杂交研究比较，批判性地评价经验建立的尖锐湿疣细胞学标准。本研究的结果表明，“典型”嗜空细胞增多症和角化异常细胞增多症并不是HPV感染存在的高度敏感的标准，只有15%的HPV - DNA阳性病例被正确识别。为了提高HPV感染细胞学诊断的敏感性，对9个“非经典”标准进行了评估。五个最有价值的征象是“轻度虚细胞增多症”、轻度角化不良、核深染、双核和多核以及细胞质清透。结合使用这些标准，统计判别分析可以正确识别84%的HPV阳性组。
The cytologic diagnosis of cervical condyloma is based on criteria developed over the last 10 years. It has now become possible to document the presence of human papilloma virus (HPV) DNA directly in cervical swabs by the highly sensitive technique of DNA filter hybridization in situ. The purpose of this article is to evaluate critically the empirically established cytologic criteria of condyloma by comparing them with HPV‐DNA hybridization studies in the same material. The results of this study indicate that ‘classic’ koilocytosis and dyskeratocytosis are not highly sensitive criteria for the presence of HPV infection, identifying only 15% of the HPV‐DNA‐positive cases correctly. In an attempt to improve the sensitivity of the cytologic diagnosis of HPV infections, a panel of nine ‘nonclassic’ criteria was evaluated. The five most valuable signs were ‘mild koilocytosis,’ mild dyskeratocytosis, hyperchromatic nuclei, bi‐ and multinucleation, and cleared cytoplasm. Using these criteria in combination, statistically discriminant analysis could correctly identify 84% of the HPV‐positive group.
从疣状表皮发育不良患者中分离人乳头瘤病毒：人泌尿生殖肿瘤中存在相关病毒 DNA 基因组。
DOI：
10.1073/pnas.79.14.4437
发表时间：
1982
影响因子：
11.1
作者：
Green,M;Brackmann,KH;Sanders,PR;Loewenstein,PM;Freel,JH;Eisinger,M;Switlyk,SA
通讯作者：
Switlyk,SA