Letter: Molecular symmetry axes and subunit interfaces in certain dehydrogenases.
Letter: Molecular symmetry axes and subunit interfaces in certain dehydrogenases.
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字母：某些脱氢酶中的分子对称轴和亚基界面。
DOI：
10.1016/0022-2836(73)90491-9
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发表时间：
1973
影响因子：
5.6
通讯作者：
Laurence Webb
中科院分区：
文献类型：
--
作者：
Michael G. Rossmann;Margaret J. Adams;Manfred Buehner;Geoffrey C. Ford;Marvin L. Hackert;Anders Liljas;S. Rao;Leonabd J. Banaszak;Edward J. Hill;Demetrius Tsernoglou;Laurence Webb
一组右手正交轴 P、Q、R 已被定义为与乳酸脱氢酶的三个不同分子 2 倍轴重合。然后可以将四种不同的对称相关亚基用红色、黄色、绿色和蓝色进行颜色编码，以识别任何一个亚基与其余三个其他亚基形成的三种不同的亚基接触。该命名法已扩展到可溶性苹果酸脱氢酶，并将有助于脱氢酶与相关三级和四级结构的比较。
A right-handed orthogonal set of axesP,Q,Rhas been denned coincident with the three different molecular 2-fold axes of lactate dehydrogenase. The four different symmetry-related subunits can then be color-coded red, yellow, green and blue to identify the three different subunit contacts made by any one subunit to the remaining three others. This nomenclature has been extended to soluble malate dehydrogenase and will facilitate the comparison of dehydrogenases with related ternary and quaternary structures.