Aortic Arch Calcification and Bone-Associated Molecules in Peritoneal Dialysis Patients.
Aortic Arch Calcification and Bone-Associated Molecules in Peritoneal Dialysis Patients.
复制标题
腹膜透析患者的主动脉弓钙化和骨相关分子。
DOI：
10.1159/000496657
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Nitta K.
中科院分区：
文献类型：
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作者：
Tsukada M;Miwa N;Hanafusa N;Tanaka N;Tsuchiya K;Nitta K.
主动脉弓钙化（AoAC）是透析中的致命并发症。AoAC进展相关分子在持续性非卧床腹膜透析（CAPD）仍不清楚。MethodsAoAC估计使用普通胸部X线摄影评分（AoACS）在30 CAPD患者（年龄49.3±13.4岁）。AoAC进展定义为研究结束时随访胸部X线检查显示AoACS增加（进展者）。成纤维细胞生长因子-23和骨保护素（OPG）measured.ResultsMedian随访时间为38.5个月。与非进展者（183.4±68.2 pg/mL; p= 0.0400）相比，进展者年龄更大，PD时间更短，体重指数更高，血清OPG水平更高（255.6±109.2 pg/mL）。进展者的脉压（62.4±20.0 mm Hg）和脉搏波速度（1，909.9 ±310.6 cm/s）也高于非进展者（分别为48.5±13.6 mm Hg; p= 0.0030和1，390.1 ±252.8 cm/s; p= 0.0005）。OPG可能与CAPD中的AoAC进展相关。
Background/AimsAortic arch calcification (AoAC) is a fatal complication in dialysis. AoAC progression-related molecules in continuous ambulatory peritoneal dialysis (CAPD) remain unclear.MethodsAoAC was estimated using plain chest radiography scoring (AoACS) in 30 CAPD patients (age 49.3±13.4 years). AoAC progression was defined as increased AoACS on follow-up chest X-ray at the end of the study (progressors). Fibroblast growth factor-23 and osteoprotegerin (OPG) were measured.ResultsMedian follow-up was 38.5 months. Progressors were older, had shorter PD vintage, higher body mass index, and higher serum OPG levels (255.6±109.2 pg/mL) than nonprogressors (183.4±68.2 pg/mL; p= 0.0400). Progressors also showed higher pulse pressure (62.4±20.0 mm Hg) and pulse wave velocity (1,909.9±310.6 cm/s) than nonprogressors (48.5±13.6 mm Hg; p= 0.0030 and 1,390.1±252.8 cm/s; p= 0.0005, respectively).ConclusionAoAC progression was associated with increased aortic stiffness. OPG may be associated with AoAC progression in CAPD.