Patients with true mixed growth hormone and prolactin-secreting pituitary adenoma: a case series of 12 patients
Patients with true mixed growth hormone and prolactin-secreting pituitary adenoma: a case series of 12 patients
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真正的混合生长激素和泌乳素分泌型垂体腺瘤患者：12 例患者的病例系列
DOI：
10.1080/02688697.2020.1713989
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发表时间：
2020-01
影响因子：
1.1
通讯作者：
Lei Sun
中科院分区：
文献类型：
--
作者：
Daqiq Gulbadin;Zhiwei Li;Muhammad Shahbaz;Zeeshan Farhaj;Arzoo Shabbir;Qichao Qi;Kuanxiao Tang;Shilei Ni;Lei Sun
摘要目的：生长激素（GH）和催乳素（PRL）混合型腺瘤是垂体多激素腺瘤中最常见的类型。我们评估了经蝶手术（TS）对GH和PRL混合腺瘤患者的临床表现和影响，包括手术结果、并发症和预后。方法和患者：12例患者（男7例，女5例）在山东大学附属齐鲁医院神经外科接受手术。我们分析了术前，术后（24小时内）和12个月随访时的激素水平，并将其与肿瘤体积相关。结果如下：缓解率66.7%（8/12），复发率16.7%（2/12），病死率16.7%（2/12）。GH、PRL和胰岛素样生长因子-1（IGF-1）水平在术前和术后显著下降，平均值分别为52.6至9.9 ng/ml（p = 0.0015）、321.6至190.9 ng/ml（p = 0.0026）和815.7至230.6 ng/ml（p = 0.0004）。这种下降在术前和随访之间更为显著，平均值分别为52.6至3.0 ng/ml（p = 0.002）、321.6至61.6 ng/ml（p < 0.0001）和815.7至195.0 ng/ml（p = 0.0001）。然而，肿瘤体积与所有激素水平之间没有显着相关性。结论：大多数GH和PRL混合腺瘤具有侵袭性，复发和死亡风险高。
Abstract Objective: Mixed growth hormone (GH) and prolactin (PRL) secreting adenomas are the most common type of plurihormonal pituitary adenomas. We assessed the clinical presentations and impacts of transsphenoidal surgery (TS) on patients with mixed GH and PRL adenomas including surgical outcomes, complications, and prognosis. Method and patients: Twelve patients (7 males, 5 females) were operated in the neurosurgery department of Qilu hospital affiliated to Shandong University, Shandong, China. We analyzed hormone levels of preoperation, postoperation (within 24 h) and at 12-month follow-up and correlated levels with tumor volumes. Results: The remission rate was 66.7% (8/12), the recurrence rate was 16.7% (2/12), the cause-specific mortality was 0 and the overall mortality rate was 16.7% (2/12) due to stroke and myocardial infarction respectively. A significant drop was seen in GH, PRL, and Insulin-like-growth-factor-1 (IGF-1) levels between preoperation and postoperation with mean values from 52.6 to 9.9 ng/ml (p = 0.0015), from 321.6 to 190.9 ng/ml (p = 0.0026) and from 815.7 to 230.6 ng/ml (p = 0.0004), respectively. This drop was more significant between preoperation and follow-up with mean values from 52.6 to 3.0 ng/ml (p = 0.002), from 321.6 to 61.6 ng/ml (p < 0.0001), and from 815.7 to 195.0 ng/ml (p = 0.0001), respectively. However, there was no significant correlation between tumor volume and all of the hormone levels. Conclusions: Most mixed GH and PRL adenomas are aggressive with a high risk of recurrence and mortality.
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影响因子：
5.8
作者：
Min Wang;Chengzhi Mou;Meng Jiang;Lizhang Han;Shengqiang Fan;C. Huan;Xin Qu;T. Han;Yuanming Qu;Guang-Ming Xu
通讯作者：
Min Wang;Chengzhi Mou;Meng Jiang;Lizhang Han;Shengqiang Fan;C. Huan;Xin Qu;T. Han;Yuanming Qu;Guang-Ming Xu
影响因子：
3.3
作者：
Françoise Robert;Georges Pelletier;Omar Serri;J. Hardy
通讯作者：
Françoise Robert;Georges Pelletier;Omar Serri;J. Hardy
影响因子：
158.5
作者：
Klibanski, Anne
通讯作者：
Klibanski, Anne
影响因子：
12.7
作者：
Trouillas, Jacqueline;Roy, Pascal;Raverot, Gerald
通讯作者：
Raverot, Gerald
影响因子：
4.1
作者：
Jonathan Rick;Arman Jahangiri;P. Flanigan;Ankush Chandra;S. Kunwar;L. Blevins;M. Aghi
通讯作者：
Jonathan Rick;Arman Jahangiri;P. Flanigan;Ankush Chandra;S. Kunwar;L. Blevins;M. Aghi