INHIBITION OF PROSTAGLANDIN SYNTHESIS RESTORES NORMAL HEMODYNAMICS IN CANINE HYPERDYNAMIC SEPSIS
INHIBITION OF PROSTAGLANDIN SYNTHESIS RESTORES NORMAL HEMODYNAMICS IN CANINE HYPERDYNAMIC SEPSIS
复制标题
DOI：
10.1097/00000658-198411000-00011
复制
发表时间：
1984-01-01
影响因子：
9
通讯作者：
CASEY, LC
中科院分区：
文献类型：
--
作者：
FINK, MP;MACVITTIE, TJ;CASEY, LC
本研究探讨前列腺素（PG）在高动力脓毒症中的作用。通过在腹腔内植入含有活的大肠杆菌的纤维蛋白凝块，13只长期使用器械的狗被致脓毒症。一天后，心输出量（CO）从2.80±-升高。0.22至3.72 .+-。0.32 l/min (P = 0.011)；心率（HR）从122 +-增加。8到147 .+-。6次/min (P = 0.005)；平均肺动脉压（PAP）从15.0±±升高。1 ~ 19 .+-。1 mm Hg (P = 0.003)；平均全身动脉压（MAP）从120 .+-下降。5到107 .+-。7毫米汞柱；全身血管阻力（SVR）从44.1 +-下降。2.6到29.3 .+-。1.9 mm Hg/l / min （P < 0.001）。静脉注射吲哚美辛（2mg /kg）或布洛芬（25mg /kg） 60min后，CO降至2.60±。0.21 l/min (P < 0.001)；人力资源减少到118 +-。5次/min (P < 0.001)；PAP降至17.0 +-。1 mm Hg (P = 0.021)；SVR升高至43.7 mm Hg/l / min （P < 0.001）。在7只对照犬中，单独剖腹手术对这些参数没有显著影响。输注吲哚美辛引起MAP轻微升高（106 .+-）。4到116 .+-。4 mm Hg, P = 0.035)，但其他方面没有改变血流动力学。结论是，吲哚美辛或布洛芬的管理恢复正常的血流动力学在犬模型的高输出脓毒症，可能是通过抑制PG合成。
This study investigates the role of prostaglandins (PG) in hyperdynamic sepsis. Thirteen chronically instrumented dogs were rendered septic by implanting in the peritoneal cavity a fibrin clot containing viable Escherichia coli. One day later, cardiac output (CO) increased from 2.80 .+-. 0.22 to 3.72 .+-. 0.32 l/min (P = 0.011); heart rate (HR) increased from 122 .+-. 8 to 147 .+-. 6 beats/min (P = 0.005); mean pulmonary artery pressure (PAP) increased from 15 .+-. 1 to 19 .+-. 1 mm Hg (P = 0.003); mean systemic arterial pressure (MAP) decreased from 120 .+-. 5 to 107 .+-. 7 mm Hg; and systemic vascular resistance (SVR) decreased from 44.1 .+-. 2.6 to 29.3 .+-. 1.9 mm Hg/l per min (P < 0.001). Sixty minutes after i.v. injection of indomethacin (2 mg/kg) or ibuprofen (25 mg/kg), CO decreased to 2.60 .+-. 0.21 l/min (P < 0.001); HR decreased to 118 .+-. 5 beats/min (P < 0.001); PAP decreased to 17 .+-. 1 mm Hg (P = 0.021); and SVR increased to 43.7 mm Hg/l per min (P < 0.001). In 7 control dogs, laparotomy alone did not significantly affect any of these parameters. Infusion of indomethacin caused a slight increase in MAP (106 .+-. 4 to 116 .+-. 4 mm Hg, P = 0.035) but otherwise did not alter hemodynamics. It is concluded that administration of indomethacin or ibuprofen restores normal hemodynamics in a canine model of high-output sepsis, probably by inhibiting PG synthesis.