Approaches toward the genetic analysis of complex traits: asthma and atopy.
Approaches toward the genetic analysis of complex traits: asthma and atopy.
复制标题
复杂性状的遗传分析方法：哮喘和特应性。
DOI：
10.1034/j.1398-9995.1999.00090.x
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发表时间：
1999
期刊：
影响因子：
12.4
通讯作者：
Marsh,DG
中科院分区：
文献类型：
--
作者：
Marsh,DG
随着对人类基因组的分析和解释所带来的挑战，以及与追求基因组计划本身有关的具体问题，这确实是生物科学发展中令人兴奋的时刻。随着复杂性理论、自然选择理论和还原论被整合成一个新的整体，新概念和新思想出现的时机当然已经成熟。我们需要学习如何处理基因组计划产生的复杂数据集的分析，并更普遍地解决分析哮喘等复杂疾病所固有的问题。最后，我们需要考虑遗传学和基因组学的最新进展将如何影响下一个千年及以后的生物医学研究。
With the challenges emerging from the analysis and interpretation of the human genome, and the specific issues pertinent to pursuing the Genome Project itself, it is truly an exciting time in the development of the biological sciences. The occasion is certainly ripe for the emergence of new concepts and ideas, as the theories of complexity, natural selection, and reductionism become integrated into a new whole. We need to learn how to approach the analyses of the complex data sets that will be generated by the Genome Project and address, more generally, the problems inherent in the analysis of the complex diseases such as asthma. Finally, we need to consider how the recent advances in genetics and genomics will affect biomedical research reaching into the next millennium and beyond.