Melanoma Thickness Trends in the United States, 1988-2006
Melanoma Thickness Trends in the United States, 1988-2006
复制标题
DOI：
10.1038/jid.2009.328
复制
发表时间：
2010-03-01
影响因子：
6.5
通讯作者：
Weinstock, Martin A.
中科院分区：
文献类型：
--
作者：
Criscione, Vincent D.;Weinstock, Martin A.
在过去的二十年里，在美国和世界范围内，已经开始了许多努力来改善黑色素瘤的筛查和早期检测。通常认为这些努力有助于稳定黑色素瘤死亡率，并且具有不利预后的厚黑色素瘤的比例正在下降。从1988-2006年国家癌症研究所监测流行病学和最终结果（SEER）计划的17个基于人群的癌症登记处获得的数据用于检查黑色素瘤肿瘤厚度的趋势。对于记录厚度的恶性黑色素瘤病例，在19年的研究期间，四种厚度类别（4 mm）之间的比例分布保持相对稳定，然而，对于导致死亡的黑色素瘤，厚肿瘤的比例增加。最大的变化发生在原位黑色素瘤的比例上，从1988年到2006年几乎翻了一番。在美国，监测和早期发现的努力并没有导致具有解剖学上不利厚度的肿瘤比例的实质性降低。需要持续改进和新的筛查方法，特别是在厚肿瘤发生率较高的人口中。
Over the past two decades, numerous efforts have been initiated to improve screening and early detection of melanoma both in the United States and worldwide. it is commonly believed that these efforts have contributed to the stabilization of melanoma mortality, and that the proportion of thick melanoma With unfavorable prognosis is on the decline. Data obtained from 17 population-based cancer registries of the Surveillance Epidemiology and End Result (SEER) program of the National Cancer Institute for 1988-2006 were used to examine trends in melanoma tumor thickness. For malignant melanoma cases with recorded thickness, the proportionate distribution among four thickness categories (4 mm) remained relatively stable over the 19-year study period, however, for melanomas resulting in death, the proportion of thick tumors increased. The most substantial change occurred in the proportion of melanoma in situ, which nearly doubled from 1988 to 2006. Surveillance and early detection efforts in the United States have not resulted in a Substantial reduction in the proportion of tumors with prognostically unfavorable thickness. Continued improvement and new methods of screening, especially among demographics with higher incidence of thick tumors, is necessary.