A functional difference in information processing between orbitofrontal cortex and ventral striatum during decision-making behaviour.
A functional difference in information processing between orbitofrontal cortex and ventral striatum during decision-making behaviour.
复制标题
决策行为过程中眶额皮层和腹侧纹状体之间信息处理的功能差异。
DOI：
10.1098/rstb.2013.0472
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Redish,ADavid
中科院分区：
文献类型：
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作者：
Stott,JeffreyJ;Redish,ADavid
眶额皮质（OFC）和腹侧纹状体（vStr）都被认为是决策任务中代表价值信息的关键结构。然而，如何处理这些信息的动态尚未被理解。我们记录了参与空间调整延迟折扣任务的大鼠OFC和vStr细胞的集合，这是一项涉及延迟和奖励幅度之间权衡的决策任务。在大鼠做出决定之前，纹状体的神经活动发出了关于奖励的信号，而这种与奖励相关的信号在OFC中不存在，直到动物做出决定之后。这些数据支持vStr直接参与行动选择的模型，但OFC随后处理与决策相关的信息，这些信息可用于比较行为的预测和实际后果。
Both orbitofrontal cortex (OFC) and ventral striatum (vStr) have been identified as key structures that represent information about value in decision-making tasks. However, the dynamics of how this information is processed are not yet understood. We recorded ensembles of cells from OFC and vStr in rats engaged in thespatial adjusting delay-discounting task, a decision-making task that involves a trade-off between delay to and magnitude of reward. Ventral striatal neural activity signalled information about reward before the rat's decision, whereas such reward-related signals were absent in OFC until after the animal had committed to its decision. These data support models in which vStr is directly involved in action selection, but OFC processes decision-related information afterwards that can be used to compare the predicted and actual consequences of behaviour.