Inactivation of myostatin by photooxygenation using functionalized D-peptides
Inactivation of myostatin by photooxygenation using functionalized D-peptides
复制标题
使用功能化 D 肽通过光氧作用灭活肌肉生长抑制素
DOI：
10.1039/d2md00425a
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发表时间：
2023
期刊：
影响因子：
4.1
通讯作者：
and Yoshio Hayashi
中科院分区：
文献类型：
--
作者：
Hideyuki Okamoto;Shuko Amber Murano;Kaoru Ikekawa;Masahiro Katsuyama;Sho Konno;Akihiro Taguchi;Kentaro Takayama;Atsuhiko Taniguchi;and Yoshio Hayashi
抑制肌生长抑制素是治疗肌萎缩症等肌萎缩症的一种有吸引力的策略。为了有效抑制肌肉生长抑制素，通过将16个分子的肌肉生长抑制素结合d肽与光氧化催化剂偶联而开发出功能化肽。这些肽在近红外照射下诱导肌生成抑制素选择性光氧化和失活，并且几乎没有细胞毒性或光毒性。由于它们的d肽链，肽对酶消化具有抗性。这些特性可能有助于在体内使用针对肌肉生长抑制素的基于光氧的失活策略。
Inhibition of myostatin is an attractive strategy for the treatment of muscular atrophic diseases such as muscular dystrophy. For the efficient inhibition of myostatin, functionalized peptides were developed by the conjugation of a 16-mer myostatin-binding D-peptide with a photooxygenation catalyst. These peptides induced myostatin-selective photooxygenation and inactivation under near-infrared irradiation, and were associated with little cytotoxicity or phototoxicity. The peptides are resistant to enzymatic digestion due to their D-peptide chains. These properties could contribute to the in vivo use of photooxygenation-based inactivation strategies targeting myostatin.