Enhanced behavioral response to repeated-dose cocaine in adolescent rats
Enhanced behavioral response to repeated-dose cocaine in adolescent rats
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DOI：
10.1007/s00213-005-0159-4
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发表时间：
2005-12-01
影响因子：
3.4
通讯作者：
Kuhn, CM
中科院分区：
文献类型：
--
作者：
Caster, JM;Walker, QD;Kuhn, CM
基本原理：人类大多数终身药物成瘾起源于青春期。大脑的重要结构和功能变化发生在青春期，但很少有直接研究表明这对药物滥用的脆弱性有何影响。一个新兴的文献表明，青少年表现出不同的行为反应，单剂量的几种成瘾性药物，包括乙醇，安非他明和可卡因。然而，很少有研究探讨重复给药的行为反应，这是人类滥用这些物质的特征。目的：我们调查了成年人和青少年对急性“狂欢”可卡因治疗的年龄相关行为反应。结果：青少年大鼠表现出夸张的行为反应，可卡因管理在两个不同的狂欢模式。可卡因给药后的总运动量在青少年和成人中是相同的。然而，青少年大鼠从事更激烈的刻板行为，包括爪子踩踏，头部编织，并集中嗅比成年大鼠。这些差异在适度剂量的可卡因后可观察到，并且在狂欢中的后续剂量后变得更加稳健。在任何接触阶段，血液和大脑中的皮质醇水平在年龄组之间没有显著差异。结论：这些发现表明，同等组织浓度的可卡因在年轻大鼠中产生更大的行为反应，并且青春期动物显示出明显的狂欢致敏形式。
Rationale: Most lifelong drug addiction in humans originates during adolescence. Important structural and functional changes in the brain occur during adolescence, but there has been little direct study of how this impacts on drug abuse vulnerability. An emerging literature suggests that adolescents exhibit different behavioral responses to single doses of several addictive drugs, including ethanol, amphetamine, and cocaine. However, few studies have explored behavioral responses to the repeated dosing that is characteristic of human abuse of these substances. Objectives: We have investigated age-related behavioral responses to acute "binge" cocaine treatment between adults and adolescents. Results: Adolescent rats displayed an exaggerated behavioral response to cocaine administered in two different binge patterns. Total locomotion after cocaine administration was the same in adolescents and adults. However, adolescent rats engaged in more intense stereotypic behaviors, including paw treading, head weaving, and focused sniffing than adult rats. These differences were observable following a modest dose of cocaine and became more robust following subsequent doses within a binge. Cocaine blood and brain levels were not significantly different between age groups during any of the exposure sessions. Conclusions: These findings suggest that equivalent tissue concentrations of cocaine produce a greater behavioral response in young rats, and that adolescent animals display an apparent form of intrabinge sensitization.