One-step synthesis of amphiphilic hyperbranched amylopectin derivatives, characterization and use as functional nanovehicles.
One-step synthesis of amphiphilic hyperbranched amylopectin derivatives, characterization and use as functional nanovehicles.
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DOI：
10.1016/j.carbpol.2013.07.007
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发表时间：
2013-10
影响因子：
11.2
通讯作者：
Di Zeng;Jizhou Fan;Zhibin Deng;Jiayun Tan;Zheng Deng;Li‐Ming Zhang;Liqun Yang
中科院分区：
文献类型：
--
作者：
Di Zeng;Jizhou Fan;Zhibin Deng;Jiayun Tan;Zheng Deng;Li‐Ming Zhang;Liqun Yang
支链淀粉是一种具有极高分子量的天然超支化生物聚合物。此外，该材料在性质上是无毒的，并且表现出良好的生物相容性和生物降解性。在这里，我们描述了一个一步反应策略的发展，用于合成具有疏水壳和大亲水核的两亲性高分子量超支化支链淀粉衍生物。所得材料的化学结构，其特征在于使用FTIR光谱，固态13 C交叉极化/魔角旋转NMR光谱和气相色谱。透射电子显微镜、荧光光谱和紫外-可见光谱分析结果表明，超支化支链淀粉衍生物由胆固醇残基疏水壳和亲水支链淀粉核组成。这些支链淀粉衍生物对水溶性分子具有很高的包封能力，可作为功能性纳米载体用于水溶性分子的控制释放和金属纳米粒子的原位合成。
Amylopectin is a naturally hyperbranched biopolymer with an extremely high molecular weight. Furthermore, this material is non-toxic in nature, and exhibits good biocompatibility and biodegradability properties. Herein, we describe the development of a one-step reaction strategy for the synthesis of amphiphilic high-molecular-weight hyperbranched amylopectin derivatives with hydrophobic shells and large hydrophilic cores. The chemical structures of the resulting materials were characterized using FTIR spectroscopy, solid-state13C cross-polarization/magic angle spinning NMR spectroscopy and gas chromatography. The results from transmission electron microscopy, fluorescence spectroscopy, and UV–vis analysis confirmed that the hyperbranched amylopectin derivatives were composed of hydrophobic shells with cholesteryl residues and hydrophilic amylopectin cores. These amylopectin derivatives exhibited high encapsulation capabilities toward water-soluble molecules, and could be used as functional nanovehicles for the controlled release of water-soluble molecules, and thein situsynthesis of metallic nanoparticles.