25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services
25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services
复制标题
DOI：
10.1212/wnl.0b013e3181beecb7
复制
发表时间：
2010-01-05
期刊：
影响因子：
9.9
通讯作者：
Tucker, K. L.
中科院分区：
文献类型：
--
作者：
Buell, J. S.;Dawson-Hughes, B.;Tucker, K. L.
背景：维生素D缺乏对神经认知健康和皮质下功能有潜在的不良影响。然而，没有研究探讨维生素D状态、痴呆和脑血管病（CVD）的头颅MRI指标之间的关系。方法：对接受家庭护理的老年人进行25-羟基维生素D [25（OH）D]、痴呆和CVD MRI测量的横断面调查结果：318例受试者中，平均年龄73.5 ± 8.1岁，女性231例（72.6%），黑人109例（34.3%）。25（OH）D浓度不足（
Background: Vitamin D deficiency has potential adverse effects on neurocognitive health and subcortical function. However, no studies have examined the association between vitamin D status, dementia, and cranial MRI indicators of cerebrovascular disease (CVD).Methods: Cross-sectional investigation of 25-hydroxyvitamin D [25(OH) D], dementia, and MRI measures of CVD in elders receiving home care (aged 65-99 years) from 2003 to 2007.Results: Among 318 participants, the mean age was 73.5 +/- 8.1 years, 231 (72.6%) were women, and 109 (34.3%) were black. 25(OH) D concentrations were deficient (