Definition of erythroid cell-positive blood transcriptome phenotypes associated with severe respiratory syncytial virus infection.
Definition of erythroid cell-positive blood transcriptome phenotypes associated with severe respiratory syncytial virus infection.
复制标题
与严重呼吸道合胞病毒感染相关的红系细胞阳性血液转录组表型的定义。
DOI：
10.1002/ctm2.244
复制
发表时间：
2020-12
影响因子：
10.6
通讯作者：
Chaussabel D
中科院分区：
文献类型：
--
作者：
Rinchai D;Altman MC;Konza O;Hässler S;Martina F;Toufiq M;Garand M;Kabeer BSA;Palucka K;Mejias A;Ramilo O;Bedognetti D;Mariotti-Ferrandiz E;Klatzmann D;Chaussabel D
Biomarkers to assess the risk of developing severe respiratory syncytial virus (RSV) infection are needed. We conducted a meta‐analysis of 490 unique profiles from six public RSV blood transcriptome datasets. A repertoire of 382 well‐characterized transcriptional modules was used to define dominant host responses to RSV infection. The consolidated RSV cohort was stratified according to four traits: “interferon response” (IFN), “neutrophil‐driven inflammation” (Infl), “cell cycle” (CC), and “erythrocytes” (Ery). We identified eight prevalent blood transcriptome phenotypes, of which three Ery+ phenotypes comprised higher proportions of patients requiring intensive care. This finding confirms on a larger scale data from one of our earlier reports describing an association between an erythrocyte signature and RSV disease severity. Further contextual interpretation made it possible to associate this signature with immunosuppressive states (late stage cancer, pharmacological immunosuppression), and with a population of fetal glycophorin A+ erythroid precursors. Furthermore, we posit that this erythrocyte cell signature may be linked to a population of immunosuppressive erythroid cells previously described in the literature, and that overabundance of this cell population in RSV patients may underlie progression to severe disease. These findings outline potential priority areas for biomarker development and investigations into the immune biology of RSV infection. The approach that we developed and employed here should also permit to delineate prevalent blood transcriptome phenotypes in other settings. Immune determinants of respiratory syncytial virus (RSV) disease severity remain ill‐defined. We conducted a meta‐analysis of six public RSV blood transcriptome datasets. Severe patients molecular phenotypes presented traits associated with immunosuppressive states and extramedullary erythropoiesis signatures.
登录
查看更多内容
影响因子：
3
作者：
Liu TY;Burke T;Park LP;Woods CW;Zaas AK;Ginsburg GS;Hero AO
通讯作者：
Hero AO
影响因子：
3.7
作者：
Linsley PS;Speake C;Whalen E;Chaussabel D
通讯作者：
Chaussabel D
影响因子：
3.7
作者：
Brand HK;Ahout IM;de Ridder D;van Diepen A;Li Y;Zaalberg M;Andeweg A;Roeleveld N;de Groot R;Warris A;Hermans PW;Ferwerda G;Staal FJ
通讯作者：
Staal FJ
DOI：
10.1056/nejmoa0804877
发表时间：
2009-02-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hall CB;Weinberg GA;Iwane MK;Blumkin AK;Edwards KM;Staat MA;Auinger P;Griffin MR;Poehling KA;Erdman D;Grijalva CG;Zhu Y;Szilagyi P
通讯作者：
Szilagyi P
影响因子：
64.8
作者：
Elahi, Shokrollah;Ertelt, James M.;Kinder, Jeremy M.;Jiang, Tony T.;Zhang, Xuzhe;Xin, Lijun;Chaturvedi, Vandana;Strong, Beverly S.;Qualls, Joseph E.;Steinbrecher, Kris A.;Kalfa, Theodosia A.;Shaaban, Aimen F.;Way, Sing Sing
通讯作者：
Way, Sing Sing