Phosphorylcholine-containing antigens in bacteria from the mouth and respiratory tract
Phosphorylcholine-containing antigens in bacteria from the mouth and respiratory tract
复制标题
DOI：
10.1099/00222615-44-1-35
复制
发表时间：
1996-01-01
影响因子：
3
通讯作者：
Lewin, J
中科院分区：
文献类型：
--
作者：
Gillespie, SH;Ainscough, S;Lewin, J
通过酶免疫分析方法，在来自口腔和呼吸道的 269 株细菌分离株中寻找含磷酰胆碱 (PC) 的抗原，只有 41 株 (15%) 分离株呈 PC 阳性，其中 29 株 (70%) 为流感嗜血杆菌菌株。产生阳性结果的其他物种包括五株溶血双子菌菌株中的两株、五株微球菌属菌株中的两株以及各一株芽孢杆菌属、杰氏棒状杆菌、乳球菌属和副流感嗜血杆菌。流感嗜血杆菌中含有PC的抗原的存在可能是检测呼吸道标本中肺炎链球菌C-多糖抗原的抗原检测技术中交叉反应的重要来源，并会导致假阳性结果。
Phosphorylcholine (PC)-containing antigens were sought in 269 bacterial isolates from the mouth and respiratory tract by an enzyme immunoassay method, Only 41 (15%) isolates were PC-positive and of these 29 (70%) were strains of Haemophilus influenzae, Other species that produced positive results included two of five isolates of Gemella haemolysans, two of five isolates of Micrococcus spp., and a single strain each of Bacillus sp., Corynebacterium jeikeium, Lactococcus sp, and H. parainfluenzae. The presence of PC-containing antigens in H. influenzae may be an important source of cross-reaction in antigen detection techniques that detect the C-polysaccharide antigen of Streptococcus pneumoniae in respiratory specimens and would result in false positive results.