Tongue and tonsil carcinoma - Increasing trends in the US population ages 20-44 years
Tongue and tonsil carcinoma - Increasing trends in the US population ages 20-44 years
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DOI：
10.1002/cncr.20998
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发表时间：
2005-05-01
期刊：
影响因子：
6.2
通讯作者：
Jordan, RCK
中科院分区：
文献类型：
--
作者：
Shiboski, CH;Schmidt, BL;Jordan, RCK
背景资料。据报道，在美国和欧洲，年轻人的口腔癌发病率不断上升。虽然人类乳头瘤病毒感染与扁桃体癌之间的关系现在已经得到了很好的证实，但据作者所知，年轻人中扁桃体癌的发病趋势知之甚少。本研究的目的是探讨口腔和咽鳞状细胞癌(SCC)在美国年轻人群中的发病趋势，特别是舌头和扁桃体鳞状细胞癌。方法利用1973-2001年监测、流行病学和最终结果(SEER)数据库，我们计算了口腔和咽癌(不包括鼻咽癌)发病率的年龄、种族和特定部位的趋势。结果：从1973年到2001年，在SEER项目中，20-44岁的成年人共报告了2262例口腔鳞癌和1251例咽部鳞癌。在年轻白人中，口腔舌鳞状细胞癌(APC=+2.1；P<；0.001)、舌根鳞状细胞癌(APC=+1.7；P=0.04)和腭扁桃体鳞状细胞癌(APC+3.9；P<；0.001)的发生率显著增加，而口腔和咽部其他部位的鳞癌发生率下降或保持不变。这可能表明，在年轻人群中，影响腭扁桃体和舌头的鳞状细胞癌的病因相似。(C)2005年美国癌症协会。
BACKGROUND. An increasing incidence of oral carcinoma among young adults has been reported in the U.S. and Europe. Although the association between human papillomavirus infection and tonsillar carcinoma is now well established, to the authors' knowledge little is known about incidence trends in tonsillar carcinoma among younger adults. The objective of the current study was to explore the trends in both oral cavity and pharyngeal squamous cell carcinoma (SCC) in younger U.S. populations, in particular tongue and tonsillar SCC.METHODS. Using the 1973-2001 Surveillance, Epidemiology and End Results (SEER) database, we computed age, race, and site-specific trends of oral and pharyngeal (excluding nasopharynx) carcinoma incidence rates. The percent change (PC) and annual percent change (APC) were computed to explore trends in incidence rates over time.RESULTS. There were 2262 SCC of the oral cavity and 1251 SCC of the pharynx reported to the SEER program from 1973 to 2001 in adults aged 20-44 years. There was a statistically significant increase in the incidence of oral tongue SCC (APC = +2.1; P < 0.001), base of tongue SCC (APC = +1.7; P = 0.04), and palatine tonsil SCC (APC +3.9; P < 0.001) among younger white individuals, whereas the incidence of SCC in all other oral and pharyngeal sites decreased or remained constant.CONCLUSIONS. The increase in tonsil SCC incidence from 1973 to 2001 paralleled the increase in tongue SCC, whereas SCC in all other oral and pharyngeal sites remained constant or decreased. This may suggest similar etiologic factors for SCC affecting the palatine tonsils and tongue in younger populations. (c) 2005 American Cancer Society.