Thiol-disulfide homeostasis in breast cancer patients
Thiol-disulfide homeostasis in breast cancer patients
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DOI：
10.4103/jcrt.jcrt_553_17
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发表时间：
2019-07-01
影响因子：
1.3
通讯作者：
Erel, Ozcan
中科院分区：
文献类型：
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作者：
Eryilmaz, Mehmet Ali;Kozanhan, Betul;Erel, Ozcan
目的：我们研究的目的是评估乳腺癌患者的硫醇二硫化物稳态（TDH），这是全身氧化应激的生物标志物。材料和方法：37 名乳腺癌患者和 31 名年龄匹配的健康志愿者参加了本研究。使用新型比色法分析血清天然硫醇、二硫化物和总硫醇水平以及二硫化物/天然硫醇、二硫化物/总硫醇以及天然硫醇/总硫醇比率。结果：乳腺癌患者的血清天然硫醇水平（350.39 +/- 7.15）显着低于健康对照（380.60 +/- 7.35）（P = 0.008）。乳腺癌患者的血清二硫化物水平 (24.96 +/- 0.85) 显着高于健康对照者 (19.25 +/- 1.34) (P = 0.002)。结论：据我们所知，本研究是文献中第一项调查乳腺癌患者 TDH 的研究。我们得出的结论是，氧化应激引起的 TDH 变化可能在乳腺癌的发病机制中发挥作用。
Objective: The aim of our study is to assess thiol-disulfide homeostasis (TDH), which is a biomarker of systemic oxidative stress, in breast cancer patients.Materials and Methods: Thirty-seven breast cancer patients and 31 age-matched healthy volunteers were enrolled in this study. Serum native thiol, disulfide, and total thiol levels and disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were analyzed using a novel colorimetric method.Results: Serum native thiol level was statistically significantly lower in breast cancer patients (350.39 +/- 7.15) than in healthy controls (380.60 +/- 7.35) (P = 0.008). Serum disulfide level was statistically significantly higher in breast cancer patients (24.96 +/- 0.85) than in healthy controls (19.25 +/- 1.34) (P = 0.002).Conclusion: To our knowledge, this study is the first study in the literature that investigated TDH in breast cancer patients. We have concluded that an alteration in TDH due to oxidative stress is likely to have a role in the pathogenesis of breast cancer.