Vaporization as a smokeless cannabis delivery system: A pilot study
Vaporization as a smokeless cannabis delivery system: A pilot study
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DOI：
10.1038/sj.clpt.6100200
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发表时间：
2007-11-01
影响因子：
6.7
通讯作者：
Benowitz, N. L.
中科院分区：
文献类型：
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作者：
Abrams, D. I.;Vizoso, H. P.;Benowitz, N. L.
虽然大麻可能具有潜在的治疗价值，但吸入燃烧产物是一种不受欢迎的输送系统。这项研究的目的是研究使用Volcano(R)装置作为吸入型大麻的另一种输送方式的汽化。18名健康的住院患者被招募，将通过雾化传递大麻类药物与在标准香烟中吸烟的大麻进行比较。在6个研究日中的每一天，随机分配一种浓度(1.7、3.4或6.8%四氢大麻酚(THC))和递送系统。主要观察指标为血浆Delta-9-THC浓度、呼出一氧化碳(CO)浓度、生理和神经心理效应。THC的血药浓度峰值和6h血药浓度-时间曲线下面积相似。CO水平随汽化而降低。未发生不良事件。蒸发大麻是一种安全有效的THC运送方式。对大麻临床有效性的进一步试验可以利用雾化作为一种无烟输送系统。
Although cannabis may have potential therapeutic value, inhalation of a combustion product is an undesirable delivery system. The aim of the study was to investigate vaporization using the Volcano (R) device as an alternative means of delivery of inhaled Cannabis sativa. Eighteen healthy inpatient subjects enrolled to compare the delivery of cannabinoids by vaporization to marijuana smoked in a standard cigarette. One strength (1.7, 3.4, or 6.8% tetrahydrocannabinol (THC)) and delivery system was randomly assigned for each of the 6 study days. Plasma concentrations of Delta-9-THC, expired carbon monoxide (CO), physiologic and neuropsychologic effects were the main outcome measures. Peak plasma concentrations and 6-h area under the plasma concentration-time curve of THC were similar. CO levels were reduced with vaporization. No adverse events occurred. Vaporization of cannabis is a safe and effective mode of delivery of THC. Further trials of clinical effectiveness of cannabis could utilize vaporization as a smokeless delivery system.