Malnutrition is Associated with Behavioral and Psychiatric Symptoms of Dementia in Older Women with Mild Cognitive Impairment and Early-Stage Alzheimer's Disease
Malnutrition is Associated with Behavioral and Psychiatric Symptoms of Dementia in Older Women with Mild Cognitive Impairment and Early-Stage Alzheimer's Disease
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DOI：
10.3390/nu11081951
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发表时间：
2019-08-01
期刊：
影响因子：
5.9
通讯作者：
Sakurai, Takashi
中科院分区：
文献类型：
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作者：
Kimura, Ai;Sugimoto, Taiki;Sakurai, Takashi
我们研究了741名记忆诊所患者的营养状况及其与痴呆症（BPSD）的行为精神症状的关系（正常认知（NC），152;轻度认知障碍（MCI），271;早期阿尔茨海默病（AD），318）。营养状况和BPSD分别采用简易营养评估简表（MNA-SF）和痴呆行为障碍量表（DBD）进行评估。与NC受试者相比，MCI和早期AD受试者中营养不良风险（MNA-SF，8-11：NC，34.2%; MCI，47.5%;早期AD，53.8%）和营养不良（MNA-SF，0-7：NC，4.6%; MCI，5.9%;早期AD，8.2%）的受试者更多。在MCI或早期AD患者中，有营养不良风险/营养不良的患者的DBD评分高于营养良好的患者（12.7 +/- 9.0 vs. 9.5 +/- 7.3; p < 0.001）。此外，调整混杂因素的协方差分析显示，营养状况与特定的BPSD显著相关，包括言语攻击/情绪去抑制（F = 5.87，p = 0.016）和冷漠/记忆障碍（F = 15.38，p < 0.001），这是由DBD的因素分析揭示的。我们的研究结果表明，营养不良是常见的老年人轻度认知功能下降，营养问题的可能性与个人BPSD。
We examined the nutritional status and its association with behavioral psychiatric symptoms of dementia (BPSD) among 741 memory clinic patients (normal cognition (NC), 152; mild cognitive impairment (MCI), 271; early-stage Alzheimer disease (AD), 318). Nutritional status and BPSD were assessed using the Mini Nutritional Assessment Short-Form (MNA-SF) and the Dementia Behavior Disturbance Scale (DBD), respectively. Compared to subjects with NC, more subjects with MCI and early-stage AD were at risk of malnutrition (MNA-SF, 8-11: NC, 34.2%; MCI, 47.5%; early-stage AD, 53.8%) and were malnourished (MNA-SF, 0-7: NC, 4.6%; MCI, 5.9%; early-stage AD, 8.2%). Among patients with MCI or early-stage AD, those at risk of/with malnutrition showed higher DBD scores than those well-nourished (12.7 +/- 9.0 vs. 9.5 +/- 7.3; p < 0.001). Moreover, analysis of covariance adjusting for confounders showed that nutritional status was significantly associated with specific BPSD, including verbal aggressiveness/emotional disinhibition (F = 5.87, p = 0.016) and apathy/memory impairment (F = 15.38, p < 0.001), which were revealed by factor analysis of DBD. Our results suggest that malnutrition is common among older adults with mild cognitive decline, and possibility that nutritional problems are associated with individual BPSD.