Functionality of arousal-regulating brain circuitry at rest predicts human cognitive abilities.
Functionality of arousal-regulating brain circuitry at rest predicts human cognitive abilities.
复制标题
休息时调节唤醒的大脑回路的功能可以预测人类的认知能力。
DOI：
10.1101/2024.01.09.574917
复制
发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Cole,MichaelW
中科院分区：
文献类型：
--
作者：
Podvalny,Ella;Sanchez-Romero,Ruben;Cole,MichaelW
唤醒状态是由脑干蓝斑核（brainstem nucleus blueruleus）调节的，蓝斑核向大脑皮层发出广泛的投射。这种强大的神经调节系统是如何被招募来帮助认知的，这在很大程度上还没有被探索。在这里，我们假设选择的皮层区域可能激活唤醒系统，这反过来又调节大规模的大脑活动，创建一个电路，其完整性预测认知能力。我们使用了人类连接组项目7T功能磁共振成像数据集（N=149），在休息时采集，同时进行眼动跟踪，沿着对每个受试者进行广泛的认知评估。首先，我们发现了特定的额顶叶皮层区域，这些区域可能通过唤醒系统驱动大规模的自发性大脑活动。其次，我们发现，由双侧后扣带皮层（与默认模式网络相关）驱动的唤醒回路的完整性预测了受试者的认知能力。这表明，通常与自我参照处理相关的皮层区域通过调节唤醒系统来支持认知。
Arousal state is regulated by the brainstem nucleus locus coeruleus, which sends wide-reaching projections to cortex. How this powerful neuromodulatory system is recruited to aid cognition is largely underexplored. Here, we hypothesized that select cortical regions may activate the arousal system, which in turn modulates large-scale brain activity, creating a circuit whose integrity predicts cognitive ability. We utilized the Human Connectome Project 7T functional magnetic resonance imaging dataset (N=149), acquired at rest with simultaneous eye tracking, along with extensive cognitive assessment for each subject. First, we discovered select frontoparietal cortical regions that likely drive large-scale spontaneous brain activity specifically via engaging the arousal system. Second, we show that the integrity of the arousal circuit driven by bilateral posterior cingulate cortex (associated with the default mode network) predicts subjects’ cognitive abilities. This suggests that a cortical region that is typically associated with self-referential processing supports cognition by regulating the arousal system.