New Immunotherapy Strategies in Breast Cancer.
New Immunotherapy Strategies in Breast Cancer.
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乳腺癌的新免疫治疗策略
DOI：
10.3390/ijerph14010068
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发表时间：
2017-01-12
影响因子：
--
通讯作者：
Chen XP
中科院分区：
文献类型：
--
作者：
Yu LY;Tang J;Zhang CM;Zeng WJ;Yan H;Li MP;Chen XP
乳腺癌是女性中最常见的癌症。乳腺癌的治疗方法通常包括手术、化疗、放疗、内分泌治疗和分子靶向治疗。随着分子生物学、免疫学和药物基因组学的发展，免疫治疗成为乳腺癌治疗的一个新领域。本文综述了乳腺癌免疫治疗的最新进展，包括癌症疫苗、双特异性抗体和免疫检查点抑制剂。还强调了发展早期阶段的几种其他免疫治疗方式。据信，这些新的免疫策略将最终改变乳腺癌治疗的现状。
Breast cancer is the most commonly diagnosed cancer among women. Therapeutic treatments for breast cancer generally include surgery, chemotherapy, radiotherapy, endocrinotherapy and molecular targeted therapy. With the development of molecular biology, immunology and pharmacogenomics, immunotherapy becomes a promising new field in breast cancer therapies. In this review, we discussed recent progress in breast cancer immunotherapy, including cancer vaccines, bispecific antibodies, and immune checkpoint inhibitors. Several additional immunotherapy modalities in early stages of development are also highlighted. It is believed that these new immunotherapeutic strategies will ultimately change the current status of breast cancer therapies.