Initial genetic characterization of the 1918 ''Spanish'' influenza virus
Initial genetic characterization of the 1918 ''Spanish'' influenza virus
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DOI：
10.1126/science.275.5307.1793
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发表时间：
1997-03-21
期刊：
影响因子：
56.9
通讯作者：
Fanning, TG
中科院分区：
文献类型：
--
作者：
Taubenberger, JK;Reid, AH;Fanning, TG
1918 年至 1919 年间，“西班牙”流感大流行造成至少 2000 万人死亡，成为历史上最严重的传染病大流行。了解 1918 年病毒的起源及其异常毒力的基础可能有助于预测未来的流感大流行。从福尔马林固定、石蜡包埋的肺组织样本中分离出 1918 年流感大流行受害者的 RNA。对血凝素、神经氨酸酶、核蛋白、基质蛋白 1 和基质蛋白 2 编码区的 9 个病毒 RNA 片段进行了测序。这些序列与一种新型 H1N1 甲型流感病毒一致，该病毒属于感染人类和猪的毒株亚组，而不是禽亚组。
The ''Spanish'' influenza pandemic killed at least 20 million people in 1918-1919, making it the worst infectious pandemic in history. Understanding the origins of the 1918 virus and the basis for its exceptional virulence may aid in the prediction of future influenza pandemics. RNA from a victim of the 1918 pandemic was isolated from a formalin-fixed, paraffin-embedded, lung tissue sample. Nine fragments of viral RNA were sequenced from the coding regions of hemagglutinin, neuraminidase, nucleoprotein, matrix protein 1, and matrix protein 2. The sequences are consistent with a novel H1N1 influenza A virus that belongs to the subgroup of strains that infect humans and swine, not the avian subgroup.