A Preliminary Examination of the Relationship Between the 5-HTTLPR and Childhood Emotional Abuse on Depressive Symptoms in 10-12-Year-Old Youth.
A Preliminary Examination of the Relationship Between the 5-HTTLPR and Childhood Emotional Abuse on Depressive Symptoms in 10-12-Year-Old Youth.
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5-HTTLPR 与童年情感虐待对 10-12 岁青少年抑郁症状关系的初步检验。
DOI：
10.1037/a0031121
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Amstadter,AnandaB
中科院分区：
文献类型：
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作者：
Banducci,AnneN;Gomes,Melissa;MacPherson,Laura;Lejuez,CW;Potenza,MarcN;Gelernter,Joel;Amstadter,AnandaB
儿童情绪虐待(CEA)是一种普遍存在的问题，与消极的后遗症有关，如抑郁症状的增加。关键的压力相关基因，如5-HTTLPR多态，与童年虐待相互作用，在青春期较大的女孩中产生更高的抑郁症状，但在青春期较大的男孩中不会。到目前为止，研究还没有具体地或在更年轻的青少年中考察这种关系作为CEA的作用。为了扩展先前的工作，我们检查了5-HTTLPR和CEA对10-12岁青年抑郁症状的影响。基于先前的发现，我们预期CEA对所有青少年的抑郁症状有主要作用，但只预期5-HTTLPR和CEA对女孩抑郁症状有交互作用。在本研究中，222名青年(平均年龄11.02岁，女生44.1%，高加索人51.6%，非裔美国人33.0%，拉丁裔2.7%，其他12.7%)及其父母(S)/监护人(S)完成了修订的儿童焦虑和抑郁量表和儿童创伤问卷中的情绪虐待子量表，并为5-HTTLPR的基因分型提供了唾液样本。结果表明，CEA，而不是5-HTTLPR，与男孩抑郁症状的增加有关。在女孩中，5-HTTLPR的S等位基因的每个拷贝都与抑郁症状的增加有关，但仅限于那些经历过CEA的人。我们的结果通过专门检查CEA和关注10-12岁的年轻人来扩展先前的发现。这些结果虽然是初步的，但表明关注推测的遗传标记和更广泛的环境事件之间的相互作用，例如CEA，可能会让研究人员确定不同的因素，对抑郁症状中后来出现的性别差异产生不同的影响。
Childhood emotional abuse (CEA) is a pervasive problem associated with negative sequelae such as elevated depressive symptoms. Key stress-related genes, such as the 5-HTTLPR polymorphism, interact with childhood abuse to produce elevated depressive symptoms in older adolescent girls, but not in older adolescent boys. To date, studies have not examined this relationship as a function of CEA specifically or among younger adolescents. To extend prior work, we examined the effects of the 5-HTTLPR and CEA on depressive symptoms among 10–12-year-old youth. Based on previous findings, we expected a main effect of CEA on depressive symptoms among all youth, but only expected an interactive effect between the 5-HTTLPR and CEA on depressive symptoms in girls. In the current study, 222 youth (mean age 11.02 years, 44.1% girls, 51.6% Caucasian, 33.0% African American, 2.7% Latino, and 12.7% other) and their parent (s)/guardian (s) completed the Revised Child Anxiety and Depression Scale and the Emotional Abuse subscale of the Childhood Trauma Questionnaire and provided saliva samples for genotyping the 5-HTTLPR. Results indicate that CEA, but not the 5-HTTLPR, was related to elevated depressive symptoms among boys. Among girls, each copy of the s allele of the 5-HTTLPR was related to increased depressive symptoms, but only for those who had experienced CEA. Our results extend prior findings by specifically examining CEA and by focusing on 10–12-year-old youth. These results, although preliminary, suggest that focusing on the interplay between putative genetic markers and a broader range of environmental events, such as CEA, might allow researchers to determine factors differentially influencing the later emergence of sex differences in depressive symptoms.(PsycInfo Database Record (c) 2020 APA, all rights reserved)