Correlation of Blood Metal Concentrations with Cognitive Scores and Neuroimaging Findings in Patients with Total Joint Arthroplasty.
Correlation of Blood Metal Concentrations with Cognitive Scores and Neuroimaging Findings in Patients with Total Joint Arthroplasty.
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DOI：
10.3233/jad-221182
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发表时间：
2023
影响因子：
4
通讯作者：
Vassilaki, Maria
中科院分区：
文献类型：
--
作者：
Beba, Alican;Peterson, Stephanie M.;Brennan, Peter C.;O'Byrne, Jamie;Machulda, Mary M.;Jannetto, Paul I.;Vemuri, Prashanthi;Lewallen, David G.;Kremers, Hilal Maradit;Vassilaki, Maria
关键词：
全关节置换术(TJA)植入物由金属、陶瓷和/或聚乙烯组成。研究表明，金属植入物释放的碎片可能具有神经毒性特性，并有神经精神症状和记忆障碍的报道，这可能与阿尔茨海默病和相关痴呆有关。这项探索性研究在113名有钛、钴和/或铬血液金属浓度升高病史的TJA患者中，考察了血液金属浓度与认知能力和神经影像结果的横断面相关性。观察到了与神经成像测量的关联，但与认知分数无关。有必要进行更大规模的纵向随访研究。
Total joint arthroplasty (TJA) implants are composed of metals, ceramics, and/or polyethylene. Studies suggest that the debris released from metal implants may possess neurotoxic properties with reports of neuropsychiatric symptoms and memory deficits, which could be relevant to Alzheimer’s disease and related dementias. This exploratory study examined the cross-sectional correlation of blood metal concentrations with cognitive performance and neuroimaging findings in a convenience sample of 113 TJA patients with history of elevated blood metal concentrations of either titanium, cobalt and/or chromium. Associations with neuroimaging measures were observed but not with cognitive scores. Larger studies with longitudinal follow-up are warranted.