Volatile organic compounds in plasma for the diagnosis of esophageal adenocarcinoma: a pilot study
Volatile organic compounds in plasma for the diagnosis of esophageal adenocarcinoma: a pilot study
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DOI：
10.1016/j.gie.2015.11.031
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发表时间：
2016-10-01
影响因子：
7.7
通讯作者：
Dweik, Raed
中科院分区：
文献类型：
--
作者：
Bhatt, Amit;Parsi, Mansour A.;Dweik, Raed
背景和目标：一种可以在早期发现食管腺癌（EAC）的非侵入性筛查试验可以改善与EAC相关的预后。血浆中挥发性有机化合物（VOCs）的诊断EAC的作用还没有以前studyed.Methods：血浆样本收集前与EAC和GERD的主题内镜。结果：共检测了39份血浆样品（EAC 20份，GERD 19份）的顶空成分。与GERD患者相比，EAC患者中9种VOC（乙腈、丙烯腈、二硫化碳、异戊二烯、1-庚烯、3-甲基己烷、[ E]-2-壬烯、硫化氢和三乙胺）的水平显著改变。多因素Logistic回归分析建立EAC的预测模型。该模型以0.83的曲线下面积（95%可信区间0.67-0.98）识别EAC患者。需要更大规模的研究来证实我们的初步研究观察结果。
Background and Aims: A noninvasive screening test that can detect esophageal adenocarcinoma (EAC) at an earlier stage could improve the prognosis associated with EAC. The role of plasma volatile organic compounds (VOCs) for the diagnosis of EAC has not been previously studied.Methods: Plasma samples were collected from subjects with EAC and GERD before endoscopy. Twenty-two preselected VOCs were analyzed with selected ion flow tube mass spectrometry.Results: The headspaces from 39 plasma samples (20 EAC, 19 GERD) were analyzed. The levels of 9 VOCs (acetonitrile, acrylonitrile, carbon disulfide, isoprene, 1-heptene, 3-methylhexane, [ E]-2-nonene, hydrogen sulfide, and triethylamine) were significantly altered in EAC patients compared with GERD patients. A multivariable logistic regression analysis was performed to build a model for the prediction of EAC. The model identified patients with EAC with an area under the curve of 0.83 (95% confidence interval, 0.67-0.98).Conclusions: Plasma VOCs may be useful in diagnosing EAC. Larger studies are needed to confirm our pilot study observations.