Pre-treatment with curcumin enhances plasma concentrations of losartan and its metabolite EXP3174 in rats.
Pre-treatment with curcumin enhances plasma concentrations of losartan and its metabolite EXP3174 in rats.
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DOI：
10.1248/bpb.35.145
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发表时间：
2012-02
影响因子：
2
通讯作者：
An-chang Liu;Li-xia Zhao;J. Xing;Tian Liu;Fuying Du;H. Lou
中科院分区：
文献类型：
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作者：
An-chang Liu;Li-xia Zhao;J. Xing;Tian Liu;Fuying Du;H. Lou
本研究在Wistar大鼠中进行，以研究姜黄素预处理对单次经口给药后高血压治疗药物氯沙坦及其代谢产物EXP 3174的药代动力学的影响。治疗组大鼠在连续灌胃姜黄素100 mg/kg后灌胃氯沙坦10 mg/kg，连续7 d;对照组大鼠仅灌胃相同剂量的氯沙坦。结果表明，姜黄素显著增加氯沙坦及其代谢产物EXP 3174的血药浓度。本研究提示姜黄素与氯沙坦之间存在中药相互作用，姜黄素给药过程中可能的相互作用有待进一步评价。
The study was carried out in the Wistar rats to investigate the effect of curcumin pre-treatment on the pharmacokinetics of the hypertension-treating drug losartan and its metabolite EXP3174 following single oral administration. In the treatment group, rats were gavaged with losartan 10 mg/kg after repeat oral doses of curcumin (100 mg/kg, for 7 d), while rats in the control group were administrated only with the same dose losartan. The results showed that curcumin significantly increased the plasma concentrations of losartan and its metabolite EXP3174. The present study implicated the existence of herb-drug interaction between curcumin and losartan, and further evaluation of the possible interaction during curcumin administration needs to be considered.