Dissemination from a Solid Tumor: Examining the Multiple Parallel Pathways.
Dissemination from a Solid Tumor: Examining the Multiple Parallel Pathways.
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DOI：
10.1016/j.trecan.2017.12.002
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发表时间：
2018-01
期刊：
影响因子：
18.4
通讯作者：
Searson PC
中科院分区：
文献类型：
--
作者：
Katt ME;Wong AD;Searson PC
Metastasis can be generalized as a linear sequence of events whereby halting one or more steps in the cascade may reduce tumor cell dissemination and ultimately improve patient outcome. However, metastasis is a complex process with multiple parallel mechanisms of dissemination. Clinical strategies focus on removing the primary tumor and/or treating distant metastases through chemo- or immunotherapies. Successful strategies for blocking metastasis will need to address the parallel mechanisms of dissemination and identify common bottlenecks. Here, we review the current understanding of common pathways for tumors to disseminate. Understanding of the complexities of metastasis will guide the design of new therapies that halt dissemination.
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