Symmetry of cerebral hemodynamic indices derived from bilateral transcranial Doppler
Symmetry of cerebral hemodynamic indices derived from bilateral transcranial Doppler
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DOI：
10.1177/1051228403013003008
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发表时间：
2003-07-01
影响因子：
2.4
通讯作者：
Czosnyka, M
中科院分区：
文献类型：
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作者：
Schmidt, EA;Piechnik, SK;Czosnyka, M
目标。作者用双侧经颅多普勒(TCD)超声评价了几项脑血管血流动力学参数的半球间差值。方法：研究方法。研究对象为44名志愿者，男33人，女11人；年龄20~23岁，平均21岁。作者记录了双侧动脉的收缩、舒张期和平均血流速度(FV)以及无创性的收缩、舒张期和平均动脉压。计算的指标包括Gosling搏动指数(GPI)、自动调节指数(Mx)、临界关闭压(CCIP)和无创性脑灌注压估计值(NCPP)。所有指标平均为每侧和每例患者。计算各参数的左右相关系数(r(2))和左右差异的95%置信限。结果。各TCD指标左右两侧相关显著：r(2)，平均Fv(FVm)0.49，GPI r(2)=0.66，Mx r(2)=0.79，Ccp r(2)0.93，nCPP r(2)=0.94。左右差的95%可信区间分别为：FVM 20 cm/s、GPI 0.1 6、Mx 0.18、CCP 13 mm Hg、nCPP 4.6 mm Hg。结论。本研究为应用各种TCD衍生指数评价脑血流动力学左右对称性提供了参考价值。这些参考值对于日常评估脑血流动力学左右不对称性的临床研究是有用的。
Objective. The authors evaluated with bilateral transcranial Doppler (TCD) ultrasonography the norm of interhemispheric difference for several cerebrovascular hemodynamic parameters. Methods. Forty-four volunteers (33 male, 11 female; average age = 21 years; range, 20-23 years) were studied. The authors recorded bilateral systolic, diastolic, and mean flow velocity (FV) and noninvasive systolic, diastolic, and mean arterial blood pressure. Calculated indices included Gosling's pulsatility index (GPI), an index of autoregulation (Mx), critical closing pressure (CCIP), and a noninvasive estimator of cerebral perfusion pressure (nCPP). All indices were averaged per side and patient. For each parameter, the left-right correlation coefficient (r(2)) and the 95% confidence limit of the left-right differences were calculated. Results. All TCD-derived indices displayed significant correlations between the left and right sides: r(2), 0.49 for mean FV (FVm), r(2) = 0.66 for GPI, r(2) = 0.79 for Mx, r(2) 0.93 for CCP, and r(2) = 0.94 for nCPP. The 95% confidence intervals for the left-right differences were 20 cm/sfor FVm, 0.1 6 for GPI, 0.18 for Mx, 13 mm Hg for CCP, and 4.6 mm Hg for nCPP. Conclusions. This study gives the reference values for the assessment of left-right symmetry of cerebral hemodynamics using various TCD-derived indices. These reference values should be useful for clinical studies assessing the left-right asymmetry of cerebral hemodynamics on a daily basis.