THE COLUMBIA-UNIVERSITY SCALE FOR PSYCHOPATHOLOGY IN ALZHEIMERS-DISEASE
THE COLUMBIA-UNIVERSITY SCALE FOR PSYCHOPATHOLOGY IN ALZHEIMERS-DISEASE
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DOI：
10.1001/archneur.1992.00530280051022
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发表时间：
1992-04-01
影响因子：
--
通讯作者：
STERN, Y
中科院分区：
文献类型：
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作者：
DEVANAND, DP;MILLER, L;STERN, Y
哥伦比亚阿尔茨海默病精神病理学不确定性量表是一种新的筛选工具，可供临床医生或受过培训的外行访问者使用。 在20名患者中，一名精神病医生和一名外行访谈者之间建立了评估者间的可靠性。 在一个独立的样本91名门诊患者非常轻度至中度可能阿尔茨海默病，照顾者的线人报告说，抑郁情绪是常见的（46.2%），但很少持续（2.2%），睡眠障碍经常发生（41.8%），但从来没有严重（0%）。 妄想的特定亚型的存在与痴呆的严重程度之间存在显著但微弱的关联。 虽然报告了各种妄想症状，但它们通常是短暂的，如果护理人员纠正，患者通常会接受真相。 因此，很少有患者符合用于定义妄想的广泛或狭窄的操作标准。 先前的研究可能高估了阿尔茨海默病中精神病特征的患病率，因为没有采用标准的定义标准。 调查结果还表明，需要更广泛地评价这一工具中采用的新方法。
The Columbia Unverisity Scale for Psychopathology in Alzheimer's disease is a new screening instrument developed for use by clinicians or trained lay interviewers. Interater reliability was established between a psychiatrist and a lay interviewer in 20 patients. In an independent sample of 91 outpatients with very mild to moderate probable Alzheimer's disease, caregiver informants reported that depressed mood was common (46.2%) but rarely persistent (2.2%), and that sleep disturbance occurred frequently (41.8%) but was never severe (0%). There were significant but weak associations between the presence of specific subtypes of delusions and severity of dementia. Although a variety of delusional symptoms were reported, they were frequently transient and patients often accepted the truth if corrected by the caregiver. As a result, few patients met broad or narrow operational criteria used to define delusions. Prior studies may have overestimated the prevalence of psychotic features in Alzheimer's disease by not employing standard definitional criteria. The findings also indicate that new methodology such as that employed in this instrument needs to be evaluated more widely.