Metabolic Factors and Microinflammatory State Promote Kidney Injury in Type 2 Diabetes Mellitus Patients
Metabolic Factors and Microinflammatory State Promote Kidney Injury in Type 2 Diabetes Mellitus Patients
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DOI：
10.1080/08860220902963822
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发表时间：
2009-01-01
期刊：
影响因子：
3
通讯作者：
Wu, Wenfang
中科院分区：
文献类型：
--
作者：
Cao, Changchun;Wan, Xin;Wu, Wenfang
Objective.本研究旨在探讨2型糖尿病患者代谢综合征、微炎症状态和肾损伤因素之间的关系。方法.对2007年1月至2008年5月期间914例2型糖尿病患者进行回顾性研究。观察不同年龄组2型糖尿病患者慢性肾脏病的患病率，分析代谢综合征与慢性肾脏病的关系。我们从这个队列中随机选择了84例患者，检测他们的炎症生物标志物，包括肿瘤坏死因子α，白细胞介素-6和C反应蛋白，以研究与慢性肾脏疾病的关系。结果慢性肾脏病的患病率为39.17%（358例），有代谢因素的慢性肾脏病患病率显著高于无代谢因素的慢性肾脏病患病率（40.90% vs.17.65%，p < 0.01）。慢性肾脏病患者的代谢因子和微炎症生物标志物显著升高。具有更多异常代谢因素的患者也具有更高水平的微炎症生物标志物，以及更高的慢性肾脏疾病风险。多因素Logistic回归分析显示，收缩压、血清甘油三酯、低密度脂蛋白、年龄、糖尿病病程是2型糖尿病患者慢性肾脏病的独立危险因素。结论. 2型糖尿病代谢因子异常与微炎症状态及慢性肾脏病密切相关。高血压、高脂血症是2型糖尿病慢性肾脏病的独立危险因素。
Objective. This study examined the associations among the factors of metabolic syndrome, microinflammatory state, and kidney injury in type 2 diabetes mellitus patients. Methods. A retrospective study was conducted on 914 type 2 diabetes mellitus patients from January 2007 to May 2008. We observed the prevalence of chronic kidney disease in different groups of type 2 diabetes mellitus patients, and analyzed the association between metabolic syndrome and chronic kidney disease. We chose 84 cases randomly from this cohort to test their inflammatory biomarkers including tumor necrosis factor alpha, interleukin-6, and C-reactive protein to study the relationship to chronic kidney disease. Results. The prevalence of chronic kidney disease was 39.17% (358 patients), and patients with metabolic factors had a significantly higher prevalence of chronic kidney disease than without metabolic factors (40.90% vs. 17.65%, p < 0.01). The metabolic factors and microinflammatory biomarkers were significantly higher in patients with chronic kidney disease. Patients who had more abnormal metabolic factors also had higher levels of microinflammatory biomarkers, as well as higher risk of chronic kidney disease. Multiple logistic regression analyses revealed that systolic blood pressure, serum triglyceride, low density lipoprotein, age, and duration of diabetes were independent risk factors of chronic kidney disease in type 2 diabetes mellitus patients. Conclusions. The abnormality of metabolic factors in type 2 diabetes mellitus had a close relationship to the microinflammatory state and chronic kidney disease. Hypertension and hyperlipidemia were independent factors of chronic kidney disease in type 2 diabetes mellitus.