Amygdala volumes in childhood absence epilepsy
Amygdala volumes in childhood absence epilepsy
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DOI：
10.1016/j.yebeh.2009.08.009
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发表时间：
2009-11-01
影响因子：
2.6
通讯作者：
Caplan, Rochelle
中科院分区：
文献类型：
--
作者：
Cohen, Ayelet Schreibman;Daley, Melita;Caplan, Rochelle
儿童情绪焦虑症和注意缺陷多动障碍(ADHD)中杏仁核体积的异常，以及儿童失神癫痫(CAE)中这些诊断的高比率，促使本研究在CAE中进行杏仁核体积的研究。26例CAE儿童和23例正常儿童，年龄6.6~15.8岁，在1.5T进行MRI扫描，分割MRI图像，通过手工示踪获得杏仁核体积。CAE组和正常组之间杏仁核体积无显著差异。然而，在CAE组中，患有ADHD的儿童的杏仁核体积明显小于没有精神病理改变的CAE受试者和有情绪/焦虑诊断的受试者。在癫痫组中，癫痫发作频率较高与杏仁核更大的不对称性也有显著关系。鉴于杏仁核在儿童和青春期后期的持续发育，尽管杏仁核体积在组内没有显著差异，杏仁核体积异常与ADHD和癫痫频率的关联暗示了该疾病对杏仁核发育和CAE相关共病(如ADHD)的影响。(C)2009 Elsevier Inc.保留所有权利。
Abnormal amygdala Volumes in pediatric mood-anxiety disorders and attention deficit hyperactivity disorder (ADHD), as well as high rates of these diagnoses in childhood absence epilepsy (CAE), prompted this study of amygdala volume in CAE. Twenty-six children with CAE and 23 normal children, aged 6.6-15.8 years, underwent MRI at 1.5 T. The tissue imaged with MRI was segmented, and amygdala volumes were obtained by manual tracings. There were no significant amygdala volume differences between the CAE and normal groups. Within the CAE group, however, the children with ADHD had significantly smaller amygdala volumes than the Subjects with CAE with no psychopathology and those with mood/anxiety diagnoses. There was also a significant relationship between higher seizure frequency and greater amygdala asymmetry in the epilepsy group. Given ongoing development of the amygdala during late childhood and adolescence, despite the lack of significant group differences in amygdala volumes, the association of amygdala Volume abnormalities with ADHD and seizure frequency implies a possible impact of the disorder on amygdala development and CAE-associated comorbidities, such as ADHD. (C) 2009 Elsevier Inc. All rights reserved.