COVID-19 Testing, Epidemic Features, Hospital Outcomes, and Household Prevalence, New York State-March 2020
COVID-19 Testing, Epidemic Features, Hospital Outcomes, and Household Prevalence, New York State-March 2020
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DOI：
10.1093/cid/ciaa549
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发表时间：
2020-10-15
影响因子：
11.8
通讯作者：
Zucker, Howard A.
中科院分区：
文献类型：
--
作者：
Rosenberg, Eli S.;Dufort, Elizabeth M.;Zucker, Howard A.
背景美国2019冠状病毒病（COVID-19）疫情自2020年2月以来大幅增长，相关住院人数及死亡率大幅上升;纽约州已成为全国疫情中心。我们报告的范围内的测试和测试结果，在3月在纽约州，沿着的风险因素，结果和家庭患病率在最初的情况下进行深入调查。用于COVID-19检测的样本采集在医疗机构、社区采集点和家庭检测团队进行。通过流行病学调查和电子病历匹配获得病例的人口统计学、危险因素和医院结局信息，并进行总结。对初始病例的家庭进行主动检测，以估计家庭患病率。3月期间，在纽约市以外的纽约州，在141495次检测中，共有47326人对严重急性呼吸系统综合征冠状病毒2型检测呈阳性（33%检测呈阳性），大都会地区各县的病例数最多。截至3月12日确诊的229例初始病例中，截至3月30日，13%住院，2%死亡。在这些病例家庭的498名成员中进行的检测发现，57%的人普遍感染，不包括38%的首次报告病例。在这些家庭中，我们发现患病率有明显的年龄梯度，< 5 years to 68% among those >≥ 65岁的占23%（P < .0001）。于二零二零年三月，纽约州面临重大且不断增加的COVID-19疫情。最早的病例在其家庭中感染率很高，到月底，住院和死亡的风险很高。
Background. Me US' coronavirus disease 2019 (COVID-19) epidemic has grown extensively since February 2020, with substantial associated hospitalizations and mortality; New York State has emerged as the national epicenter. We report on the extent of testing and test results during the month of March in New York State, along with risk factors, outcomes, and household prevalence among initial cases subject to in-depth investigations.Methods. Specimen collection for COVID-19 testing was conducted in healthcare settings, community-based collection sites, and by home testing teams. Information on demographics, risk factors, and hospital outcomes of cases was obtained through epidemiological investigations and an electronic medical records match, and summarized descriptively. Active testing of initial case's households enabled estimation of household prevalence.Results. During March in New York State, outside of New York City, a total of 47 326 persons tested positive for severe acute respiratory syndrome coronavirus 2, out of 141 495 tests (33% test-positive), with the highest number of cases located in the metropolitan region counties. Among 229 initial cases diagnosed through 12 March, by 30 March 13% were hospitalized and 2% died. Testing conducted among 498 members of these case's households found prevalent infection among 57%, excluding first-reported cases 38%. In these homes, we found a significant age gradient in prevalence, from 23% among those < 5 years to 68% among those >= 65 years (P < .0001).Conclusions. New York State faced a substantial and increasing COVID-19 outbreak during March 2020. The earliest cases had high levels of infection in their households and by the end of the month, the risks of hospitalization and death were high.