Sialylation using N-glycolylneuraminyl phosphite donors to synthesize Neu5Gc-containing glycans
Sialylation using N-glycolylneuraminyl phosphite donors to synthesize Neu5Gc-containing glycans
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DOI：
10.1016/j.carres.2009.03.004
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发表时间：
2009-05-26
影响因子：
3.1
通讯作者：
Sato, Ken-ichi
中科院分区：
文献类型：
--
作者：
Hanashima, Shinya;Tomiya, Taku;Sato, Ken-ichi
在含Neu 5Gc的聚糖的合成中描述了使用在乙醇酰基部分上具有乙酰基或苄基的N-乙醇酰基神经氨酸（Neu 5Gc）亚磷酸酯供体的有效唾液酸化。亚磷酸酯给体1和2两者在丙腈中在-78 ° C下容易地与伯和仲受体醇偶联以提供具有良好α-选择性的所需糖苷。(C)2009爱思唯尔有限公司保留所有权利。
Efficient sialylations using N-glycolylneuraminic acid (Neu5Gc) phosphite donors having an acetyl or benzyl group on the glycolyl moiety are described in the synthesis of Neu5Gc-containing glycans. Both phosphite donors 1 and 2 were readily coupled with primary and secondary acceptor alcohols in propionitrile at -78 degrees C to provide the desired glycosides with good alpha-selectivities. (C) 2009 Elsevier Ltd. All rights reserved.