Recognition of human oncogenic viruses by host pattern-recognition receptors.
Recognition of human oncogenic viruses by host pattern-recognition receptors.
复制标题
DOI：
10.3389/fimmu.2014.00353
复制
发表时间：
2014
影响因子：
7.3
通讯作者：
Di Paolo NC
中科院分区：
文献类型：
--
作者：
Di Paolo NC
人类致癌病毒包括EB病毒、B型肝炎病毒、C型肝炎病毒、人类乳头状瘤病毒、人类T细胞嗜淋巴细胞病毒、卡波西相关肉瘤病毒和默克尔细胞多瘤病毒。在病毒与宿主相互作用期间，免疫系统将识别这些病原体并将其消灭。然而，通过进化，这些病毒已经开发出许多策略来避免这种结果并成功地建立慢性感染。由这些病毒引起的感染的持续性与它们的致癌潜力有关。本文就致瘤病毒与宿主先天免疫系统相互作用的最新研究进展作一综述。特别是，我们将总结现有的知识识别宿主模式识别受体的病原体相关的分子模式存在于传入的病毒颗粒或在病毒的生命周期中产生的。我们还将审查有关识别病毒感染期间产生的细胞衍生危险相关分子模式的数据，这些分子模式可能影响宿主-病原体相互作用的结果和癌症的发展。
Human oncogenic viruses include Epstein–Barr virus, hepatitis B virus, hepatitis C virus, human papilloma virus, human T-cell lymphotropic virus, Kaposi’s associated sarcoma virus, and Merkel cell polyomavirus. It would be expected that during virus–host interaction, the immune system would recognize these pathogens and eliminate them. However, through evolution, these viruses have developed a number of strategies to avoid such an outcome and successfully establish chronic infections. The persistent nature of the infection caused by these viruses is associated with their oncogenic potential. In this article, we will review the latest information on the interaction between oncogenic viruses and the innate immune system of the host. In particular, we will summarize the available knowledge on the recognition by host pattern-recognition receptors of pathogen-associated molecular patterns present in the incoming viral particle or generated during the virus’ life cycle. We will also review the data on the recognition of cell-derived danger associated molecular patterns generated during the virus infection that may impact the outcome of the host–pathogen interaction and the development cancer.