Enhanced Error-Related Brain Activity in Children Predicts the Onset of Anxiety Disorders Between the Ages of 6 and 9
Enhanced Error-Related Brain Activity in Children Predicts the Onset of Anxiety Disorders Between the Ages of 6 and 9
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DOI：
10.1037/abn0000044
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发表时间：
2015-05-01
影响因子：
4.6
通讯作者：
Klein, Daniel N.
中科院分区：
文献类型：
--
作者：
Meyer, Alexandria;Hajcak, Greg;Klein, Daniel N.
考虑到焦虑症经常在成年前开始，并经常导致慢性损害，重要的是要表征导致临床焦虑发作的发展途径。确定可以预测儿童焦虑发作的神经生物标志物可能会增加我们对焦虑病因的理解，并为干预和预防策略提供信息。事件相关电位（ERP），错误相关负波（ERN），已被提出作为焦虑风险的生物标志物，并且先前已与成人和儿童的焦虑相关。然而，以前的研究没有检查ERN是否可以预测焦虑症的发作。在目前的研究中，ERPs被记录，而236名健康儿童，约6岁，执行一个去/不去的任务，以测量ERN。三年后，孩子和父母回到实验室，完成了关于焦虑症状态的诊断访谈。结果表明，6岁时与错误相关的大脑活动增强预测了9岁时新的焦虑症的发作，即使在控制基线焦虑症状和母亲焦虑史的情况下。考虑到识别风险的早期生物标志物的潜在效用，这是以前工作的一个新的和重要的扩展。
Considering that anxiety disorders frequently begin before adulthood and often result in chronic impairment, it is important to characterize the developmental pathways leading to the onset of clinical anxiety. Identifying neural biomarkers that can predict the onset of anxiety in childhood may increase our understanding of the etiopathogenesis of anxiety, as well as inform intervention and prevention strategies. An event-related potential (ERP), the error-related negativity (ERN), has been proposed as a biomarker of risk for anxiety and has previously been associated with anxiety in both adults and children. However, no previous study has examined whether the ERN can predict the onset of anxiety disorders. In the current study, ERPs were recorded while 236 healthy children, approximately 6 years of age, performed a go/no-go task to measure the ERN. Three years later, children and parents came back to the lab and completed diagnostic interviews regarding anxiety disorder status. Results indicated that enhanced error-related brain activity at age 6 predicted the onset of new anxiety disorders by age 9, even when controlling for baseline anxiety symptoms and maternal history of anxiety. Considering the potential utility of identifying early biomarkers of risk, this is a novel and important extension of previous work.