Mitophagy in neurodegenerative disease pathogenesis
Mitophagy in neurodegenerative disease pathogenesis
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DOI：
10.4103/1673-5374.385281
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发表时间：
2023
影响因子：
6.1
通讯作者：
Fei Li
中科院分区：
文献类型：
--
作者：
Kan Yang;Yuqing Yan;Anni Yu;Ru Zhang;Yuefang Zhang;Zilong Qiu;Zhengyi Li;Qianlong Zhang;Shihao Wu;Fei Li
Mitochondria act as central players in the whole life of neuron by serving as energy resources. Mitophagy is a process that selectively clears damaged or dysfunctional mitochondria through autophagic machinery, functioning to maintain mitochondrial quality control and homeostasis. As its postmitotic nature and high energy consumption, mature neuron requires a highly efficient turnover of mitophagy to clear damaged or dysfunctional mitochondria. Nowadays, accumulating evidence indicates the pivotal role of mitophagy in the pathogenesis of neurological diseases. However, whether molecular participants of mitophagy are potential therapeutic targets remains elusive. In this review, we briefly discussed the characteristics of nonselective autophagy and selective autophagy including ERphagy, aggrephagy and mitophagy. We then introduced the detailed working modes of two mitophagy pathways under physiological conditions, based on Parkin-dependent or Parkin-independent manner. Next, we summarized the diverse repertoire of protein receptor and phospholipid from the mitochondria membrane that mediate mitophagy. Importantly, we reviewed the critical role of mitophagy in the pathogenesis of neurological diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS). Last, we updated the information for recent studies on the mitophagy as a potential therapeutic target for resisting neurological diseases. Together, our review may provide novel views to a better understanding in the roles of mitophagy in neurological disease pathogenesis.
