Preliminary Results of Non-Surgical Periodontal Treatment in Patients With Breast Cancer Undergoing Chemotherapy.
Preliminary Results of Non-Surgical Periodontal Treatment in Patients With Breast Cancer Undergoing Chemotherapy.
复制标题
接受化疗的乳腺癌患者非手术牙周治疗的初步结果。
DOI：
10.1902/jop.2016.160101
复制
发表时间：
2016
影响因子：
4.3
通讯作者：
D. Palioto
中科院分区：
文献类型：
--
作者：
Kelly R Vargas;F. T. Dantas;M. Messora;A. B. Novaes;M. F. Grisi;M. Taba;S. Souza;F. J. Candido dos Reis;H. Carrara;D. Palioto
背景
尽管通常优先考虑治疗癌症本身，但重点还应放在预防和改善癌症和/或其治疗可能导致的口腔并发症上。本研究通过监测临床状况和 C 反应蛋白 (CRP) 水平，比较健康患者和接受化疗的乳腺癌患者的牙周治疗结果。
方法
35 名参与者被分配到两组中的一组：牙周炎患者 (P) (n = 18) 和乳腺癌兼牙周炎患者 (CAN/P) (n = 17)。在基线以及非手术牙周治疗 (NSPT) 后 45、90 和 180 天评估以下临床参数：1) 探诊深度 (PD)； 2）临床依恋水平（CAL）； 3）菌斑指数（PI）； 4) 牙龈指数(GI)； 5）CRP； 6) 全血细胞计数。对临床参数和CRP水平进行统计分析。
结果
与基线相比，P 组和 CAN/P 组在 NSPT 后第 45 天、90 天和 180 天的 PD 显着下降（P <0.05）。 P 组的 CAL 有所增加，两组的 PI 和 GI 在 45、90 和 180 天时均显着降低（P <0.05）。 NSPT治疗后180天，与P组相比，CAN/P组显示出更多的残余袋数（P <0.05）（分别为46.48±26.80和7.58±7.40）。与基线相比，P 组在 NSPT 后 45 天和 180 天时 CRP 水平显着降低（P <0.05），而 CAN/P 组未观察到这种降低。
结论
接受化疗的乳腺癌患者对牙周非手术治疗有反应，但效果不如未患癌症的牙周炎患者，并且可能需要额外或辅助的牙周治疗。
BACKGROUND
Although priority is often given to treat the cancer itself, focus should also be directed to prevention and improvement of oral complications that may occur as a result of cancer and/or its treatment. This study compares periodontal treatment results in healthy patients and patients with breast cancer undergoing chemotherapy by monitoring clinical conditions and C-reactive-protein (CRP) levels.
METHODS
Thirty-five participants were allocated to one of two groups: patients with periodontitis (P) (n = 18) and patients with breast cancer and periodontitis (CAN/P) (n = 17). The following clinical parameters were assessed at baseline and 45, 90, and 180 days after non-surgical periodontal treatment (NSPT): 1) probing depth (PD); 2) clinical attachment level (CAL); 3) plaque index (PI); 4) gingival index (GI); 5) CRP; and 6) complete blood count. Clinical parameters and CRP levels were statistically analyzed.
RESULTS
P and CAN/P groups presented a statistically significant decrease in PD after NSPT at 45, 90, and 180 days compared with baseline (P <0.05). There was a CAL gain in the P group and a significant reduction in PI and GI at 45, 90, and 180 days for both groups (P <0.05). At 180 days after NSPT treatment, the CAN/P group showed a higher number of residual pockets (P <0.05) compared with the P group (46.48 ± 26.80 and 7.58 ± 7.40, respectively). The P group demonstrated a significant reduction in CRP levels at 45 and 180 days after NSPT compared with baseline (P <0.05), whereas this reduction was not observed in the CAN/P group.
CONCLUSION
Patients with breast cancer who were undergoing chemotherapy responded to periodontal non-surgical therapy, although with less favorable results than patients with periodontitis without cancer, and may require additional or adjunctive periodontal treatments.
乳腺癌幸存者的牙周健康、口腔健康感知和牙科护理利用。
影响因子：
2.3
作者：
Taichman,LSusan;Griggs,JenniferJ;Inglehart,MaritaR
通讯作者：
Inglehart,MaritaR
影响因子：
16.8
作者：
Hajishengallis G
通讯作者：
Hajishengallis G