Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy
Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy
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含金纳米粒子的氧化石墨烯改性PLA微胶囊用于超声/CT双模成像引导光热肿瘤治疗
DOI：
10.1016/j.biomaterials.2013.03.027
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发表时间：
2013-07-01
期刊：
影响因子：
14
通讯作者：
Dai, Zhifei
中科院分区：
文献类型：
--
作者：
Jin, Yushen;Wang, Jinrui;Dai, Zhifei
通过双微乳液法将金纳米粒子引入聚乳酸微胶囊中，然后通过静电层层自组装技术将氧化石墨烯沉积到微胶囊表面，成功制备了治疗诊断微胶囊。事实证明，所获得的微胶囊可以作为造影剂，同时在体外和体内极大地增强US成像和X射线CT成像。此外，体内治疗检查表明，微胶囊是癌症光热治疗的有效药物。在微胶囊存在的情况下，近红外激光在9天内完全消融肿瘤，肿瘤生长抑制率为83.8%。通过单一微胶囊剂将实时超声与 3D 计算机断层扫描相结合，对于准确解释所获得的图像、识别肿瘤的大小和位置以及指导和监测光热治疗非常有帮助。同时，可以通过微胶囊剂增强的超声和 CT 联合成像来评估光热疗法的有效性。这种多功能的微胶囊系统可能为下一代多模态成像引导癌症治疗带来机会。 Crown 版权所有 (C) 2013 由 Elsevier Ltd 出版。保留所有权利。
Theranostic microcapsules were successfully fabricated by introducing gold nanoparticles into poly(lactic acid) microcapsules through a double-microemulsion method, followed by depositing graphene oxide onto the microcapsule surface via electrostatic layer-by-layer self-assembly technique. It was proved that the obtained microcapsules could serve as a contrast agent to simultaneously enhance US imaging and X-ray CT imaging greatly both in vitro and in vivo. In addition, the in vivo therapeutic examinations showed that the microcapsule was an effective agent for photothermal therapy of cancer. The near-infrared laser light ablated the tumor completely within 9 days in the presence of the microcapsules and the tumor growth inhibition was 83.8%. The combination of real-time ultrasound with 3-D computed tomography through a single microcapsule agent is very helpful for accurately interpreting the obtained images, identifying the size and location of the tumor, as well as guiding and monitoring the photothermal therapy. Simultaneously, the effectiveness of photothermal therapy could be evaluated by the combined US and CT imaging enhanced by the microcapsule agent. Such a versatile microcapsule system might bring opportunities to the next generation of multimodal imaging guided cancer therapy. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.