Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study.
Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study.
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多系统萎缩中的血浆同型半胱氨酸、维生素 B12 和叶酸水平：病例对照研究
DOI：
10.1371/journal.pone.0136468
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Zhang S;Shi C;Mao C;Song B;Hou H;Wu J;Liu X;Luo H;Sun S;Xu Y
多系统萎缩（MSA）是一种神经退行性疾病，其病理标志是α-突触核蛋白的积聚。同型半胱氨酸（Hcy）是蛋氨酸代谢过程中产生的一种中间氨基酸。Hcy可能参与神经退行性疾病的发病机制。维生素B12和叶酸是同型半胱氨酸甲基化所必需的辅助因子。本研究比较了MSA患者与健康人的血清Hcy、维生素B12和叶酸水平，以揭示MSA与血浆Hcy、维生素B12和叶酸水平之间可能存在的相关性。本研究纳入了161例MSA患者和161例健康人。采用Logistic回归分析血浆Hcy、维生素B12和叶酸水平与MSA的关系。MSA患者血浆Hcy水平显著高于健康对照组（16.23 ± 8.09 μ mol/L vs 14.04 ± 4.25 μ mol/L，P < 0.05）。校正年龄、性别和病史后，MSA患者Hcy的优势比为1.07（95% CI = 1.01-1.13，p < 0.05）。维生素B12和叶酸水平在MSA患者和对照组之间没有显著差异。我们的数据表明，高水平的同型半胱氨酸可能与MSA的风险增加。
Multiple system atrophy (MSA) is a neurodegenerative disease, and its pathological hallmark is the accumulation of α-synuclein proteins. Homocysteine (Hcy) is an intermediate amino acid generated during the metabolism of methionine. Hcy may contribute to the pathogenesis of neurodegenerative disorders. Vitamin B12 and folate are cofactors necessary for the methylation of homocysteine. This study compared the levels of serum Hcy, vitamin B12 and folate in patients with MSA with those in healthy people to reveal the possible association between MSA and plasma levels of Hcy, vitamin B12 and folate. We enrolled 161 patients with MSA and 161 healthy people in this study. The association between MSA and the levels of Hcy, vitamin B12 and folate were analyzed using binary logistic regression. The mean level of Hcy in patients with MSA was significantly higher than that in healthy controls (16.23 ± 8.09 umol/l vs 14.04 ± 4.25 umol/l, p < 0.05). After adjusting for age, sex and medical history, the odds ratio for Hcy was 1.07 (95% CI = 1.01–1.13, p < 0.05) for patients with MSA. Vitamin B12 and folate levels were not significantly different between patients with MSA and controls. Our data suggest that higher levels of Hcy may be associated with an increased risk for MSA.